selective B2 adrenoceptor agonists

Question 1

cautions

Answer 1

• arrhythmias
• CVD
• diabetes
• hypertension
• hyperthyroidism
• hypokalaemia
• Qt interval

Question 2

why are they cautioned in diabetes

Answer 2

risk of hyperglycaemia and ketoacidosis esp with IV use

Question 3

caution - hypokalaemia

Answer 3

potentially serious hypokalaemia can occur from b2 agonist therapy
esp in severe asthma or COPD bc effect may be potentiated by concomitant treatment with theophylline and its derivatives, CCs, diuretics, and by hypoxia

Question 4

4 common side effects

Answer 4

arrthyhmias
headache
palpitations
tremor

Question 5

monitoring in pt with severe asthma

Answer 5

plasma potassium conc due to risk of hypokalaemia

Question 6

monitoring in pt with diabetes

Answer 6

BG due to risk of hyperglycaemia and ketoacidsosis esp when given IV

Question 7

name the prodrug of terbutaline. it is a long acting b2 agonist

Answer 7

bambuterol

Question 8

what is bambuterol

Answer 8

LABA
prodrug of the SABA terbutaline

Question 9

can bambuterol be used in P or BF

Answer 9

avoid

Question 10

what is formoterol - laba or saba

Answer 10

laba

Question 11

name 2 labas that are ONLY licensed for COPD

Answer 11

indaceterol
olodaterol

Question 12

indacaterol and olodaterol are only licensed for

Answer 12

COPD maintenance

Question 13

how often is salmeterol and formoterol (LABAS) given

Answer 13

BD
duration of action 12 hours

Question 14

how often are indacaterol and olodaterol (LABA for COPD) given?

Answer 14

OD

Question 15

name the 2 SABAs

Answer 15

salbutamol
terbutaline

Question 16

what type of inhaler is salbutamol easyhaler

Answer 16

DPI

Question 17

name the pMDIs for salbutamol

Answer 17

salamol
salamol easi breathe
ventolin evohaler
airomir
airomir autohaler

Question 18

what is the MHRA advice re use of nebulised asthma therapy in children

Answer 18

for SABAs
home use of nebulisers in paediatric pt should be initiated and managed by specialist only