Selectins, Integrins, and their Ligands

Question 1

Distribution and Ligands of P-Selectin (CD62P)?

Answer 1

Distribution: Endothelium activated by histamine or thrombin

Ligand: Sialyl Lewis X on PSGL-1 and other glycoproteins; neutrophils, monocytes, T cells (effector, memory).

Question 2

Distribution and Ligands of E-Selectin (CD62E)?

Answer 2

Distribution: Endothelium activated by cytokines (TNF, IL-1)

Ligand: Sialyl Lewis X (ex. CLA-1) on glycoproteins; neutrophils, monocytes, T cells (effector, memory)

Question 3

Distribution and Ligands of L-Selectin (CD62L)?

Answer 3

Distribution: Sialyl Lewis X/PNAd on GlyCAM-1, CD34, MadCAM-1, others; endothelium (HEV)

Question 4

Distribution and Ligands of LFA-1?

Answer 4

LFA-1 = Lymphocyte function-associated antigen 1
Distribution: Neutrophils, monocytes, T cells (naive, effector, memory), B cells (naive)

Ligand: ICAM-1 (CD54), ICAM-2 (CD102); endothelium (cytokine-induced)

Question 5

Distribution and Ligands of Mac-1?

Answer 5

Mac-1 = Macrophage-1 antigen
Distribution: Neutrophils, monocytes, dendritic cells

Ligand: ICAM-1 (CD54), ICAM-2 (CD102), endothelium (cytokine-induced)

Question 6

Distribution and Ligands of VLA-4?

Answer 6

VLA-4 = Very late antigen 4
Distribution: Monocytes, T cells (naive, effector, memory)

Ligand: VCAM-1 (CD106); endothelium (cytokine-induced)

Question 7

Distribution and Ligands of alpha4beta7?

Answer 7

Distribution: Monocytes, T cells (gut homing, naive, effector, memory), B cells (gut homing)