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WI18 Neuro > Seizure Pharm > Flashcards

Seizure Pharm Flashcards

1
Q

ADRS of ALL AED(5)

A

Increased risk of suicidality

SJS/TEN

Bone loss

Alcohol use is CI

Contraception - teratogenic and decreased effectiveness of oral contraceptives

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2
Q

general AED Drug-Drug interactions (5)

A

GI medications (antacids)

Anti-infectives (e-mycin, clarithromycin, fluconazole, antivirals)

Oral contraceptives

Warfarin

Psychiatric meds

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3
Q

when are Drug Levels Ordered?

A

After starting new drug

Following dose adjustment or addition of another drug

Recurrent seizures despite medication (poorly controlled)

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4
Q

Carbamazepine brand + indications

A

Tegretol

Indications: first line, trigeminal neuralgia

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5
Q

Carbamazepine ADRs

A

dizziness, diplopia/blurry vision, nausea, ataxia,

Rare: LFT increase (5-10%), aplastic anemia, agranulocytosis, thrombocytopenia, SJS

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6
Q

drugs induced by Carbamazepine

A

OCs
TCAs
warfarin

increase these doses

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7
Q

inducers of Carbamazepine metabolism

A

other AEDs
St Johns wort
grapefruit juice

increase CBZ dose

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8
Q

inhibitors of CBZ metabolism

A

macrocodes
CCBs
Tagament

decrease CBZ dose

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9
Q

Oxcarbazepine

brand name + why not used

A

Trileptal

May promote some types of seizures so not used

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10
Q

Phenytoin

contraindication + brand

A

Dilantin

CI: pregnancy

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11
Q

why is Dilantin CI in pregnancy?

A

Phenytoin

cleft palate, cleft lip, congenital heart disease, slowed growth rate, mental deficiency

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12
Q

Phenytoin ADRs (6)

A

osteoporosis

coarsening of facial features/gingival hyperplasia

increased body hair

CNS

loss of libidio, hormone dysfunction

vitamin K and folate deficiency

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13
Q

drugs induced by Phenytoin

A

furosemide
other AED

increase these drug dose

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14
Q

drugs inhibited by Phenytoin

A

warfarin, steroids

decrease dose

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15
Q

inducers of Phenytoin

A

other AEDs
amiodarone

increased PHT dose

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16
Q

inhibitors of Phenytoin

A

sulfonamides
tangamet

decrease PHT dose

17
Q

Fosphenytoin

brand + indications

A

Cerebyx

IV, status epilepticus tx, short term tx with oral meds

18
Q

Cerebyx ADrs

A

Fosphenytoin

cardiac depression and HoTN, rate of infusion

19
Q

Lamotrigine

brand + indications

A

Lamictil

bipolar disorder

safe in pregnancy, elderly pts

20
Q

Lamictil ADRs

A

Lamotrigine

rash, CKD dose adjust

21
Q

Valproate/Valproic Acid

brand + indications

A

Depakote

migraine HA prophylaxis, bipolar disorder

22
Q

Depakote ADRs

A

Valproate

N/v, tremor, sedation, confusion, irritability, weight gain

increased bleeding, SIADH, insulin resistance, sex hormone changes, pancreatitis and hepatotoxic

23
Q

Valproate BBW

A

pregnancy

causes fetal cognitive impairment

24
Q

drugs induced by Valproate

A

Benzos
other AEDs

increase these doses

25
Q

drugs inhibited by Valproate

A

sulfonylureas = decrease dose

26
Q

inducers of Valproate

A

other AEDs, carbapenems

increase VPA dose

27
Q

inhibitors of Valproate

A

Tagamet
e-mycin

decrease dose

28
Q

Topiramate

brand + indications

A

Topamax

migraine prophylaxis

29
Q

Topiramate ADRs

A

ataxia, impaired concentration, confusion, dizziness, fatigue, paresthesia, somnolence, depression, agitation, slowed speech

weight loss (appetite suppression)

renal calculi

30
Q

Topiramate DDI

A

Induced by: PHT, CBZ

Induce metabolism of estrogens

31
Q

Levetiracetam

Brand + indications + DDI + ADRS

A

Keppra

Indications: adults, DOC in children, elderly

ADRs: few - dizziness, somnolence, asthenia, URI

Drug-Drug: no significant DDI, can cross placenta

32
Q

Gabapentin

brand + indication + ADR

A

Neurontin

Indication: neuropathic pain, migraine HA

ADRs: Somnolence

33
Q

Pregabalin

brand + indication

A

Lyrica

migraine HA, neuropathic pain

34
Q

pregabalin

ADR

A 
dizziness
drowsiness
weight gain
difficulty concentrating
angioedema
35
Q

Zonisamide

brand + indication + adr

A

Zonegran

long half life = good for non compliance

ADRs: sulfa drug allergy

36
Q

lacosamide brand

A

vimpat

WI18 Neuro (16 decks)

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