Seizure and Parkinsons d r u g s

Question 1

Seizure involve both brain hemispheres
from the onset (1 Point) *
Focal onset seizure
Generalised onset seizure
Tonic clonic c o n v u l s i o n s
Generalized a b s e n c e seizure
Myoclonic seizure

Answer 1

Generalised onset seizure

Question 2

brief episodes of unconsciousness (4-20
seconds, usually <10 seconds) with no
warning and immediate resumption of
consciousness (no postictal abnormality).
(1 Point) *
F o c a l o n s e t s e i z u r e
G e n e r a l i z e d o n s e t s e i z u r e
• Tonic clonic convulsions
G e n e r a l i z e d a b s e n c e s e i z u r e
Myoclonic seizure

Answer 2

G e n e r a l i z ed
a b s e n c e
s e i z u r e

Question 3

sudden, brief (<100 milliseconds),
involuntary, single or multiple contractions
of muscles or muscle groups of variable
topography (axial, proximal limb, distal
limb). (1 Point) *
F o c a l o n s e t s e i z u r e
G e n e r a l i z e d o n s e t s e i z u r e
Tonic clonic convulsions
G e n e r a l i z e d a b s e n c e s e i z u r e
Myoclonic s e i z u r e

Answer 3

M y o c lonic
e s e i z u r e

Question 4

The specific actions of antiseizure drugs
on their targets are broadly described as:
(1 Point) *
modulation of voltage-gated sodium, calcium,
or potassium channels
enhancement of fast GABA-mediated synaptic
inhibition
modification of synaptic release processes
diminution of fast glutamate-mediated excita-
t i o n
all o f t h e a b o v e

Answer 4

all o f t h e a b o v e

Question 5

a sodium channel-blocking antiseizure
drug except (1 Point) *
carbamazepine
lamotrigine
diazepam
phenytoin

Answer 5

diazepam

Question 6

Inhibits COMT in CNS and peripheral
tissues that converts levodopa to 3-0-
methyldopa (3OMD) (1 Point) *
Entacapone
Levodopa
Carbidopa
Pramipexole
Bromocriptine

Answer 6

E n t a c a p o n e

Question 7

Acts as a partial agonist at dopamine D2
receptors in the brain (1 Point) *
E n t a c a p o n e
Levodopa
• C a r b i d o p a
• Pramipexole
Bromocriptine

Answer 7

Bromocriptine

Question 8

Enters the brain via a n L-amino acid
transporter (LAT) → converted to
dopamine by the enzyme aromatic L-amino
acid decarboxylase (dopa decarboxylase)
(1 Point) *
Entacapone
Levodopa
Carbidopa
Pramipexole
Bromocriptine

Answer 8

Levodopa

Question 9

High affinity for the dopamine D3 receptor,
nonergot (1 Point) *
Entacapone
Levodopa
Carbidopa
Pramipexole
Bromocriptine

Answer 9

Pramipexole

Question 10

Inhibits MAO-B selectively; higher doses
also inhibit MAO-A (1 Point) *
E n t a c a p o n e
Selegiline
Carbidopa
Pramipexole
Bromocriptine

Answer 10

Selegiline