Antipsychotics: PLQ

Question 1

A symptom of mental illness characterized
by a distorted or non-existent s e n s e of
reality:
m e n t a r e t a r d a t i o n
Illusion
Confusion
Psychosis

Answer 1

Psychosis

Question 2

One of the following is a typical symptom
of schizophrenia:
D e r a i l m e n t
Disorganized behavior
• lllusions
• Disregard for moral values

Answer 2

Disorganized behavior

Question 3

Apathy, avolition,alogia are manifestations
of schizophrenia that are typically called:
(1 Point) *
Positive symptoms
Negative symptoms
Neutral symptoms
Disorganized symptoms

Answer 3

Negative symptoms

Question 4

The latest criteria used for the diagnosis of
schizophrenia: (1 Point) *
DSM III
D S M IV
DSM V
• DSM VI

Answer 4

DSM V

Question 5

This hypothesis has led to the
development of the first therapeutic class
of antipsychotic agents, now referred to as
typical or first generation antipsychotic
drugs: (1 Point) *
Serotonin hypothesis
Glutamate excitability
Acetylcholine increased impulse transmission
Dopamine overactivity

Answer 5

Dopamine overactivity

Question 6

Typical antipsychotics differed in
potency, but shared this common and main
mechanism: (1 Point) *
• DA D1 blockade
DA D2 b l o c k a d e
• DA D3 blockade
• 5HT 2A blockade

Answer 6

DA D2 b l o c k a d e

Question 7

It is a key factor in the mechanism of action
of the main class of atypical antipsychotic
drugs,of which Clozapine is the prototype:
(1 Point) *
DA D1 blockade
DA D2 blockade
DA D3 blockade
5HT 2A blockade

Answer 7

5HT 2A blockade

Question 8

What is the limitation of the Dopamine
hypothesis in the explanation of the
symptoms of schizophrenia? (1 Point) *
-Does not account for the cognitive
deficits
-There is a fourth receptor that h a s not been
elaborated
-Does not fully explain the disorganized behav-
ior
-It totally negates the serotonin synthesis

Answer 8

Does not account for the cognitive
deficits

Question 9

Delusional disorder,schizophrenia and
schizoaffective disorder a r e d i s e a s e s that
require: (1 Point) *
Short term treatment only
Long term treatment
M e d i u m term t r e a t m e n t
Intermittent t r e a t m e nt

Answer 9

Long term treatment

Question 10

One of the following is the goal of
treatment of schizophrenia: (1 Point) *
Maximize functional recovery
• Address the negative symptoms first
Psychiatric reconditioning strategies
• Cognitive behavioral therapy

Answer 10

Maximize functional recovery