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Pharmacology CNS > CNS Module Review > Flashcards

CNS Module Review Flashcards

1
Q
  1. Which is an inhibitory neurotransmitter in response to
    increased cAMP released from cell bodies at all levels with
    short, medium and long connections?
A

Dopamine

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2
Q

Which is an inhibitory neurotransmitter in response to
increased calcium conductance released from spinal
interneurons and some brain stem interneurons?

A

Glycine

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3
Q

Which of the following i i n antagonist at benzodiazepine
binding sites on the GABA-A receptor which blocks actions of
benzodiazepines and zolpidem but not other sedative-
hypnotic drugs used in the management of benzodiazepine
o v e r d o s e ?

A

Flumazenil

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4
Q

Which benzodiazepin t h a t has positive allosteric
modulator of GABA-A receptor?

A

Retigabine

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5
Q

Which is a gabapenti vith bioavailability 50% and
decreasing with increasing oses used in focal seizures,
neuropathic pain, postherpetic neuralgia, fibromyalgia and
anxiety?

A

Pregabalin

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6
Q

Activation of mel tropic receptors located
presynaptically causes inhibition by decreasing the inward
flux of which of the following?

A

Calcium

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7
Q

Which of the following hormone play a major role in the
expression of mood states nany antidepressant drugs
are thought to increase its tunctional activity and is mostly
located in diffuse neuronal systems in the CNS, with cell
bodies particularly in the raphe nuclei?

A

Serotonin

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8
Q

Which of these neurotransmitters is found in high
concentrations in cell bodi? l e pons and brain s t e m a n d
can exert both excitatory ar bitory actions with multiple
receptor subtypes have been identified, some of which are
targets for drugs that can exert both CNS and peripheral
actions?

A

Norepinephrine

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9
Q

A 40-year-old woman had attacks of intense
anxiety with marked physical symptoms, including
hyperventilation, tachycardia, and sweating. If she is
diagnosed as suffering from a panic disorder, the most
appropriate drug to use is:

A

Alprazolam

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10
Q

Which of the following t scribes the m e c h a n i s m of
action of benzodiazepines?
A.Activate GABA-B receptors in the spinal cord
B.Block glutamate receptors in hierarchical neuronal
pathways in the brain
C. Increase frequency of opening of chloride ion channels
coupled to GABAA receptors
D.Inhibit GABA transaminase to increase brain levels of GABA

A

C. Increase frequency of opening of chloride ion channels
coupled to GABAA receptors

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11
Q

Which of the following criteria for a neurotransmitter role in the CNS?
emicals does not satisfy the
A. Acetylcholine
B.Cyclic AMP
C.Dopamine
D. Glycine

A

Cyclic AMP

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12
Q

Which of the following drugs is a voltage-gated potassium
channel inhibitor?
A. Carbamazepine
B.Phenytoin
C. Lamotrigine
D.Retigabine

A

Retigabine

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13
Q

Which of the following anti-seizure drugs inhibits GABA-
transaminase?
A. Vigabatrin
B. Tiagabine
C.Perampanel
D. Ethosuximide

A

Vigabatrin

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14
Q

The following anti-seizu:
interaction, except:
A. Levetiracetam
B.Gabapentin
C.Oxcarbazepine
D. Pregabalin

A

Oxcarbazepine

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15
Q

Which blocks binding of orexins, neuropeptides that
promote wakefulness which promotes sleep onset and
duration also used in sleep disorders?
A. Buspirone
B.Suvorexant
C.Ramelteon
D.Zolpidem

A

Suvorexant

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16
Q

Which antidepressant is the most sedating?
A. Fluoxetine.
B.Duloxetine.
C. Nortriptyline.
D.Citalopram

A

Nortriptyline

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17
Q

Which of the following strative-hypnotics decreases REM
sleep but has minimal effect on slow-wave sleep?
A.Zaleplon
B.Zolpidem
C.Eszopiclone
D.Suvorexant

A

Zolpidem

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18
Q

Which of the following second-generation antipsychotics
is a prodrug?
A. Clozapine
B.Olanzapine
C.Aripiprazole
D. Risperidone

A

Risperidone

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19
Q
  1. W h i c h of t h e • following depicts the neurotrophic
    hypothesis of depression cr tly?
    A. Effective antidep therapies i n c r e a s e
    neurogenesis and synapt connectivity in cortical areas
    such as the hippocampus.
    B.Depression is the result of the loss of monoamines.
    C. Depression is related to a deficiency in the amount or
    function o f cortical a n d limbic serotonin,
    norepinephrine, and dopamine.
    D. Depressed patients who respond to serotonergic
    antidepressants often rapidly suffer relapse when given
    diets free of tryptophan
A

A. Effective antidep therapies i n c r e a s e
neurogenesis and synapt connectivity in cortical areas
such as the hippocampus.

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20
Q

The initial phase of antidepressant therapy consists of a
trial of SSRI for weeks.
A.4-6
B.6-8
C.8-12
D. 12-16

A

C.8-12

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21
Q

Which of the following aepressants is approved for
use in the treatment of premenstrual dysmorphic disorder?
A.Duloxetine
B.Fluoxetine
C.Clomipramine
D.Imipramine

A

B.Fluoxetine

22
Q

Which of the following is true about SSRIs?
A. They are the most common antidepressants in clinical
u s e .
B. They are a class of agents that have as their primary
action the inhibition of the serotonin transporter.
C.They are highly hydrophilic.
D. They are also indicated in GAD, PTSD, OCD, panic
disorder, PMDD, and butimia

A

C.They are highly hydrophilic.

23
Q

Which of the following gs of abuse has an additional
mechanism of action that involves the interference of the
vesicular monoamine transporter inside presynaptic
t e r m i n a l s ?
A. Cocaine
B.Amphetamine
C.MDMA
D.Amyl nitrite

A

B.Amphetamine

24
Q

Exposure to cocaine in following, except:
A. Intracranial hemorrhage
B.Ischemic stroke
C.Seizures
D.Hyperthyroidism

A

D.Hyperthyroidism

25
Q

Which of the following drugs is used to augment smoking
c e s s a t i o n e f f o r t s ?
A.Acamprosate
B.Naloxone
C.Varenicline
D.Oxazepam

A

C.Varenicline

26
Q

With chronic use in seiz states, the adverse effects of
which of the following drug include coarsening of facial
features, hirsutism and gingival hyperplasia?
A. Carbamazepine
B. Ethosuximide
C. Phenytoin
D.Zonisamide

A

C. Phenytoin

27
Q

Abrupt withdrawal o seizure drugs can result in
increases in seizure frequency and severity. Withdrawal is
most easily accomplished if the patient is treated with which
among the following?
A. Carbamazepine
B. Clonazepam
C.Ethosuximide
D. Phenobarbital

A

C.Ethosuximide

28
Q

The mechanism of anti:
re activity of carbamazepine
is:
A. Block of sodium ion channels
B.Block calcium ion channels.
C.Glutamate receptor antagonism
D.Inhibition of GABA transaminase

A

A. Block of sodium ion channels

29
Q

A muscarinic receptor gonist would probably not be
n e e d e d for reversal of the skeletal m u s c l e relaxant actions of
nondepolarizing drug if the agent used was
A. Cisatracurium
B.Mivacurium
C.Pancuronium
D. Tubocurarine

A

C.Pancuronium

30
Q

Which of the following drug is the most effective in the
emergency management of malignant hyperthermia?
A. Atropine
B.Dantrolene
C.Haloperidol
D. Succinylcholine

A

B.Dantrolene

31
Q

Which drug (related t o - nidine) is most often ass
with hypotension?
A. Bactofen
B.Pancuronium
C . S u c c i n y t c h o l i n e
D.Tizanidine

A

D.Tizanidine

32
Q

Which drug is most likely t o cause hyperkalemia leading
to cardiac arrest in patients with spinal cord injuries?
A.Baclofen
B.Pancuronium
C.Succinylcholine
D.Dantrolene

A

C.Succinylcholine

33
Q

Which drug administere the operating room can be
used to prevent postoperative pain caused by
succinylcholine?
A. Atracurium
B.Baclofen
C.Dantrolene
D.Diazepam

A

A. Atracurium

34
Q

Which of the following drugs is established to be both
effective and safe to use in a pregnant patient suffering from
bipolar disorder?
A. Carbamazepine
B.Fluphenazine
C.Olanzapine
D. Valproic acid

A

C.Olanzapine

35
Q

Which drug is an antagonist at 5HT2 receptors and widely
used for the management of insomnia?
A. Estazolam
B.Flurazepam
C. Trazodone
D. Triazolam

A

C. Trazodone

36
Q

SSRI are much less effective than tricyclic
antidepressants in the management of
A. Bulimia
B.Chronic pain of neuropathic pain
C.Generalized anxiety disorder.
D.Obsessive compulsive disorder

A

B.Chronic pain of neuropathic pain

37
Q

Which of the following drugs is most likely to be of value in
obsessive-compulsive disorders?
A. Amitriptyline
B.Bupropion
C. Clomipramine
D. Trazadone

A

C. Clomipramine

38
Q

Which sign or symptom is likely to occur with marijuana?
A. Bradycardia
B.Conjunctival reddening
C.Hypertension
D.Mydriasis

A

B.Conjunctival reddening

39
Q

What is the Treatment of behavioral side effects of
levodopa?
A. Quetiapine
B.Bromocriptine
C.Selegiline
D.Escitalopram

A

A. Quetiapine

40
Q

Which of the following dopamine agonists can cause
painless digital vasospasm?
A. Pergolide
B.Pramipexole
C.Ropinirole
D.Bromocriptine

A

D.Bromocriptine

41
Q

A 52-year-old man ha: several focal complex partial
seizures over the last year. Which one of the following
therapies would be the most appropriate initial therapy for
this patient?
A. Ethosuximide
B.Levetiracetam
C.Diazepam
D. Carbamazepine plus primidone

A

B.Levetiracetam

42
Q

Which of the following is a first-line medication for
generalized tonic-clonic seizures?
A. Ethosuximide
B. F e l b a m a t e
C.Vigabatrin
D.Topiramate

A

D.Topiramate

43
Q

Which of the following is not a behavioral side effect of
levodopa?
A. Somnolence
B.Agitation
C.Flat affect

A

C.Flat affect

44
Q

Which of the following anti-Parkinson drugs is no longer
used due to its association with valvular heart disease?
A. Pergolide
B.Pramipexole
C.Ropinirole
D.Bromocriptine

A

A. Pergolide

45
Q

Which of the following anti-Parkinson drugs is
administered as a patch?
A. Rotigotine
B.Bromocriptine
C. Pramipexole
D.Pergolide

A

A. Rotigotine

46
Q

Which drug has spasmolytic activity and could also be
used in the management of seizures caused by overdose of a
local anesthetic?
A. Baclofen
B. Cyclobenzaprine
C.Diazepam
D.Gabapentin

A

C.Diazepam

47
Q

A drug of abuse that binds dopamine reuptake transporter is:
A.Alcohol
B.Cocaine
C.Marijuana
D.Nicotine

A

B.Cocaine

48
Q

A 24-year-old noted have restlessness, bruxism (tooth
grinding), skin flushing and panic attack most likely took
which drug?
A.Amphetamine
B.Cocaine
C.MDMA
D.Marijuana

A

A.Amphetamine

49
Q

Which of the following drugs inhibit alcohol
dehydrogenase?
A.Disulfiram
B.Fomepizole
C.Ketoconazole
D. Tramadol

A

B.Fomepizole

50
Q

A 51-year-old woman with symptoms of major depression
also has angle-closure glaucoma. Which of the following
antidepressants should be avoided in this patient?
A. Amitriptyline
B.Sertraline
C.Bupropion
D. Mirtazapine

A

A. Amitriptyline

Pharmacology CNS (4 decks)

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