SEE 6 Flashcards
cleomyocin is toxic to the?
lungs
cisplatin is toxic to the ?
kidneys
doxorubicin is toxic to the ?
heart
cyclophophains is toxic to the ?
liver
streptozocin is toxic to the ?
liver
methotrexate is toxic to the?
liver
where do CCB’s work?
phase 2, plateau phase of ventricular action potential & phase 4 of the pacemaker action potential
what 3 things increase the likelihood of digitalis toxicity
hypokalemia, hypercalcemia, hypomagnesemia
top 5 causes of anaphylactic reactions =
NMB, latex, abx, colloids, hypnotics.
what is the universal recipient
AB
what factors does cryoprecipitate contain
I, VIII, XIII
whats the formula for ABL
EBV x (Hct - aHCT / HCT)
whats the 4-2-1 rule
4ml/kg first 10kg, 2ml/kg second 10kg, 1ml/kg remainder….. shortcut is add 40 to total kg if >20
too much LR causes what electrolyte disturbance
metabolic alkalosis
mannitol causes ___volemia, ____kalemia, ___natremia
hypovolemia, hyperkalemia, hyponatremia
virchows triangle -
endothelial injury, stasis or truant blood flow, hypercoagulability of blood
hemophilia A = factor __ def
8
hemophilia B = factor __ def
9 (christmas)
what is the order of heat loss
radiation, convection, evaporation, conduction
what are the 2 hormones of the posterior pit
adh and oxytocin
which is more potent, T3 or T4?
T3 is 4x more potent
T_ is converted to T_ in the tissues
T4 –> T3
graves is ___ and hasimotos is ____
hyper, hypo
thyroid storm occurs ___ posted
6-8h
what are the cardiac effects of hypocalcemia
prolonged QT, dec myocardial contractility
what is the formula for anion gap
na - cl - hco3
normal is 9-15
ekg changes with hyperkalemnia
prolonged PR, widened QRS, peaked or tented T waves
ekg changes of hypokalemia
prolonged PR and QT, flattened T wave, prominent U wave
aldosterone causes sodium and water ___ and potassium and hydrogen ___
retention, excretion
addisons dz means you have ____ aldosterone
dec. so hyponatremia and hyperkalemia
cushings dz means you have
excessive cortisol. htn. hypokalemia, hyperglycemia. moon face, buff hump
conn’s dz = primary _____ characterized by __Na and ___K
hyperaldosteronism, inc NA, dec K
what is the best indicator of renal status
creatinine clearance
whats the MOA Of diamox? hint it’s a carbonic anhydrase inhibitor
inhibits carbonic anhydrase in proximal tubule which decreases Na reabsorption
___ your acids = alkalosis
puke
___ your bases = acidosis
poop
what is mendelsons
ph < 2.5, volume <25
