Sedatives and Hypnotics Flashcards
Which drugs are classified as sedatives and Hypnotics?
-with no anoxiolytic, amnestic, or anti convulsive properties
- Eszopiclone (Lunesta)
- Zolpidem (Ambien)
- Zalepon (Sonata)
- Ramelteon
- Chloral Hydrate
- Barbiturates
- ETOH
- Antihistamines
What is the MOA of Eszopiclone, Zolpidem, Zalepon?
Acts on BZ1 sites on GABA
What is the indication of Eszopiclone, Zolpidem, Zalepon?
Sedative
What is the MOA of Ramelteon?
Melatonin MT1 and MT2 agonist
-inhibitory action on excitatory wakefulness
What is the MOA of Barbiturates?
Increase GABA inhibitory action through non-BZ sites
Which drug is used for maintenance of circadian rhythm?
Ramelteon
What are the contraindications of Barbiturates?
- Acute Intermittent Porphyria
T or F: Barbiturates provide good analgesic effect?
FALSE: NO analgesia
What are the contraindications of Barbiturates?
Respiration depression
Coma
Death
Which Barbiturate is used as an anticonvulsant?
- Phenobarbital
2. Thiopental
Which sedative induces sleep in 30 min and lasts 6 hours?
Chloral hydrate
Which sedative has nightmares, sleep walking, amnesia as an adverse effect?
Sonata
Which drug is an opiate antagonist?
Naltrexone
Which drug controls seizures?
Carbamazepine
T or F: Luniest has withdrawl and tolerance with long term use.
TRUE
