Anti-Depressants Flashcards

1
Q

What are the drugs used for Depression?

A
  1. TCA’s (1,2nd, 3rd, 4th gen)
  2. Atypicals
  3. MAOI’s
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2
Q

What are the 1st get TCA’s?

A

I’m No Ami

-triptyline

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3
Q

What are the 2nd gen TCA’s?

A

Amoxapine
Maprotiline
Amox-Map

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4
Q

What are the 3rd gen TCA’s/SSRIs?

A
  1. Fluoxitene (Prozac/Sarafem)
  2. Paroxitene (Luvox)
  3. Fluvoxamine (Paxil)
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5
Q

What are the 4th gen TCA’s/SNRIs?

A
  1. Venlafaxine
  2. Deslafaxine
  3. Duloxitene (Cymbalta)
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6
Q

What is the MOA of the 3rd gen TCAs?

A

SELECTIVE inhibition of SA reuptake

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7
Q

What is the MOA of the 3rd gen TCAs/SSRIs?

A

SELECTIVE inhibition of SA reuptake

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8
Q

Narrow angle glaucoma, CNS depressants (ETOH) are contraindications for which drugs?

A

1st and 2nd gen TCA’s

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9
Q

Which TCA can be used for OCD?

A

Fluvoxamine (Luvox)

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10
Q

Which TCA has an indication of post-menstrual symptoms?

A

Fluoxitene (Prozac/Sarafem)

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11
Q

What is the advantage of 3rd gen TCAs?

A

No orthostatic Hypotension

Less cardiotoxicity

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12
Q

What is the advantage of 3rd gen TCAs/SSRIs?

A

No orthostatic Hypotension

Less cardiotoxicity

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13
Q

What are the 3rd gen TCAs indicated for?

A
Eating disorders 
Panic disorders 
Anxiety (without dependence) 
Major depression
OCD 
Post-menstrual symptoms
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14
Q

What are the 3rd gen TCAs/SSRIs indicated for?

A
Eating disorders 
Panic disorders 
Anxiety (without dependence) 
Major depression
OCD 
Post-menstrual symptoms
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15
Q

Which TCA causes Insomnia?

A

Fluoxitene/Prozac/Sarafem

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16
Q

Which anti-depressant causes Serotonin syndrome?

A

3rd gen TCA’s

17
Q

What is the MOA of the 4th gen/SNRIs?

A

SA and NE reuptake inhibitors

18
Q

What does depression = ?

A

Decreased NE

Decreased SE

19
Q

What are the indications of the SNRIs?

A

Depression
NEUROPATHIC PAIN
When SSRI’s fail

20
Q

Which two anti-depressants give sexual dysfunction as an adverse effect?

A

SSRIs

SNRIs

21
Q

Weight gain, glaucoma, and arrhythmias are adverse effects to which anti-depressants?

A

1st gen TCAs

22
Q

What are the Atypical Anti-depressants?

A
  1. Bupropion
  2. Mirtazapine
  3. Trazodone
  4. Nefazodone
23
Q

What is the MOA of Bupropion?

A

WEAK NE and DA reuptake inhibitor

24
Q

What is the MOA of Mirtazapine?

A

A2 receptor antagonist