Anti-Depressants Flashcards
What are the drugs used for Depression?
- TCA’s (1,2nd, 3rd, 4th gen)
- Atypicals
- MAOI’s
What are the 1st get TCA’s?
I’m No Ami
-triptyline
What are the 2nd gen TCA’s?
Amoxapine
Maprotiline
Amox-Map
What are the 3rd gen TCA’s/SSRIs?
- Fluoxitene (Prozac/Sarafem)
- Paroxitene (Luvox)
- Fluvoxamine (Paxil)
What are the 4th gen TCA’s/SNRIs?
- Venlafaxine
- Deslafaxine
- Duloxitene (Cymbalta)
What is the MOA of the 3rd gen TCAs?
SELECTIVE inhibition of SA reuptake
What is the MOA of the 3rd gen TCAs/SSRIs?
SELECTIVE inhibition of SA reuptake
Narrow angle glaucoma, CNS depressants (ETOH) are contraindications for which drugs?
1st and 2nd gen TCA’s
Which TCA can be used for OCD?
Fluvoxamine (Luvox)
Which TCA has an indication of post-menstrual symptoms?
Fluoxitene (Prozac/Sarafem)
What is the advantage of 3rd gen TCAs?
No orthostatic Hypotension
Less cardiotoxicity
What is the advantage of 3rd gen TCAs/SSRIs?
No orthostatic Hypotension
Less cardiotoxicity
What are the 3rd gen TCAs indicated for?
Eating disorders Panic disorders Anxiety (without dependence) Major depression OCD Post-menstrual symptoms
What are the 3rd gen TCAs/SSRIs indicated for?
Eating disorders Panic disorders Anxiety (without dependence) Major depression OCD Post-menstrual symptoms
Which TCA causes Insomnia?
Fluoxitene/Prozac/Sarafem
Which anti-depressant causes Serotonin syndrome?
3rd gen TCA’s
What is the MOA of the 4th gen/SNRIs?
SA and NE reuptake inhibitors
What does depression = ?
Decreased NE
Decreased SE
What are the indications of the SNRIs?
Depression
NEUROPATHIC PAIN
When SSRI’s fail
Which two anti-depressants give sexual dysfunction as an adverse effect?
SSRIs
SNRIs
Weight gain, glaucoma, and arrhythmias are adverse effects to which anti-depressants?
1st gen TCAs
What are the Atypical Anti-depressants?
- Bupropion
- Mirtazapine
- Trazodone
- Nefazodone
What is the MOA of Bupropion?
WEAK NE and DA reuptake inhibitor
What is the MOA of Mirtazapine?
A2 receptor antagonist
