Anti-Anxiety

Question 1

Which drugs are used to treat Anti-Anxiety?

Answer 1

1. Benzos (SA), (IA), (LA)
2. Anti-BZ
3. Buspirone
4. Hydroxyzine
5. Antidepressants

Question 2

What is the DOC for Chronic anxiety?

Answer 2

SSRI’s

Question 3

What are the SA Benzos?

Answer 3

1. Oxazepam
2. Triazolam
3. Midazolam

Question 4

What are the IA Benzos?

Answer 4

1. Alprazolam
2. Temazepam
3. Lorazepam

Question 5

What are the LA Benzos?

Answer 5

1. Diazepam
2. Flurazepam
3. Clonazepam
4. Chlordiazepoxide
5. Clorazepate

Question 6

What is the anti-BZ?

Answer 6

Flumazenil

Question 7

What is the MOA of Buspirone?

Answer 7

Stimulates Sertatonin 5HT 1A receptors

Question 8

What is the indication of Buspirone?

Answer 8

General anxiety disorder

Question 9

What is the MOA of hydroxyzine ?

Answer 9

Antihistamine and Antiemetic

Question 10

What is the indication of hydroxyzine?

Answer 10

Sedation

*for patients with a history of dependence

Question 11

Which drug used for anxiety has little habituation?

Answer 11

hydroxyzine

Question 12

Which drug used for anxiety has minimal dependence?

Answer 12

Buspirone

Question 13

Which drug used for anxiety lacks anti-convulsive and muscle relaxation?

Answer 13

Buspirone

Question 14

T or F: Buspirone has a slow onset of action.

Answer 14

True

Question 15

What is the MOA of Flumazenil?

Answer 15

Benzodiazepine antagonist

Question 16

What is the indication of Flumazenil?

Answer 16

Rapid reversal of sedation and/or OD

Question 17

What are the adverse effects of Flumazanil?

Answer 17

BZ withdrawal

• rapid onset
• short duration
• IV ONLY

Question 18

What is the DOC for infrequent events (flying)?

-also used for difficulty going to sleep

Answer 18

Triazolam (SA)

Question 19

What is the DOC for amnesia?

-used as an adjunct to anesthesia for anxiety, amnesia, and sedation

Answer 19

Midazolam (SA)

Question 20

Which SA BZ is used for ETOH withdrawal?

Answer 20

Oxazepam

Question 21

What is the DOC for Panic attacks?

Answer 21

Alprazolam (IA)

Question 22

What drug is used for frequent awakenings?

Answer 22

Temazepam (IA)

Question 23

Which drug is used for ETOH withdrawal but also used as an adjunct to anesthesia for anxiety, amnesia, and sedation?

Answer 23

Lorazepam (IA)

Question 24

What is the DOC for Severe anxiety disorders, muscle relaxation, and Grand Mal seizures (Status Epilepticus)?

Answer 24

Diazepam

Question 25

Which drugs are used for ETOH withdrawal as well as an adjunct to anesthesia for anxiety, amnesia, and sedation?

Answer 25

1. Lorazepam (IA) | 2. Diazepam (LA)

Question 26

Which drugs are used as an adjunct to anesthesia for anxiety, amnesia, and sedation?

Answer 26

1. Midazolam (SA) 2. Lorazepam (IA) 3. Diazepam (LA)

Question 27

What is the DOC for chronic epilepsy and myoclonic seizures?

Answer 27

Clonazepam

Question 28

Which 3 drugs are used for ETOH ONLY?

Answer 28

1. Oxazepam 2. Chlordiazepoxide 3. Clorazepate

Question 29

Which LA Bz is used for sleep disorders?

Answer 29

Flurazepam

Question 30

What is the MOA of ALL the Benzos?

Answer 30

Binds to an allosteric site which increases GABA's affinity for its receptor --inhibitory --Cl- influx causes hyper polarization = decreased neuronal firing

Question 31

What are the adverse effects of ALL the Benzos?

Answer 31

1. Liver disease 2. NA glaucoma 3. Hx of substance abuse 4. ETOH and other CNS depressants

Question 32

T or F: There is rapid tolerance with SA Benzos?

Answer 32

True

Question 33

T or F: the tolerance and the dependence is LESS with the IA and LA than with the SA.

Answer 33

True

Question 34

What are the 4 common adverse effects of ALL the Benzos?

Answer 34

1. Ataxia 2. Confusion 3. Cognitive impairment 4. Drowsiness (A, C,C, D)