Sedatives and General Anaesthetics

Question 1

Thiopentone drug group and indications

Answer 1

Barbiturate (ultra short acting)

Induction anaesthetic

Question 2

Propofol MOA and indications

Answer 2

MOA similar to thiopentone, rapid induction

Used for induction and maintenance of anaesthesia

Question 3

Desflurane/sevoflurane/isoflurane/methoxyflurane (liquid) MOA and indications

Answer 3

Inhaled general anaesthetics - activates TREK-1 channels, therefore opposing excitation/depolarisation

Question 4

Midazolam/temazepam/lorazepam/diazepam drug group and MOA

Answer 4

Benzodiazepines

Enhancing the actions of GABA at the GABA-a receptor site

Question 5

Ketamine MOA and indications

Answer 5

Inhibitor/antagonist of NMDA activation by binding within the NMDA channel

Used for short procedures

Question 6

Midazolam indications

Answer 6

Short acting benzodiazepine used to produce strong sedation prior to anaesthesia with another agent