Anti-depressants and Anti-manics

Question 1

Desipramine side effects

Answer 1

Due to blockade of:
Muscarinic receptors: dry mouth, blurry vision, urinary retention, constipation

H1 receptors: sedation

Alpha-1 adrenoceptors: orthostatic hypotension

Cardiac arrhythmias

Question 2

Desipramine drug group and MOA

Answer 2

Tricyclic antidepressants (TCA)

Blocks re-uptake of both NA and 5HT (mainly NA)

Question 3

Tranylcypromine drug group + side effects

Answer 3

Irreversible MAO inhibitors

Insomnia, postural hypotension, sexual dysfunction,
CHEESE REACTION

Question 4

Moclobamide drug group + side effects

Answer 4

Reversible MAO inhibitor, selective for MAOa

Minor: insomnia, nausea, no cheese reaction

Question 5

Nefazadone drug group + indications

Answer 5

Serotonin antagonist and reuptake inhibitor (SARI)

Used when patient has acute ADR, eg. anxiety when using SSRI.
Less potent than TCA, SSRI

Question 6

Reboxetine drug group

Answer 6

Noradrenaline reuptake inhibitor (NRI)

Question 7

Venlafaxine

Answer 7

Serotonin and noradrenaline reuptake inhibitor

Question 8

Fluoxetine drug group

Answer 8

SSRI (selective serotonin re-uptake inhibitor)