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Pharmacology > Anti-epileptics > Flashcards

Anti-epileptics Flashcards

1
Q

Carbamazepine indications + side effects

A

Partial seizures

Bone marrow depression, drowsiness, dizziness, blurred vision, ataxia, mental dulling

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2
Q

Ethosuximide MOA

A

Blocks T-type Ca channels in thalamic neurons

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3
Q

Ethosuximide indications

A

Absence (petit mal) seizures

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4
Q

Valproate MOA

A

Blocks GABA-transaminase (GABA metabolism)

Blocks high frequency firing through Na channels

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5
Q

Valproate indications + side effects

A

Generalised tonic-clonic (grand mal) seizures

Absence (petit mal) seizures with the use of ethosuximide

Weight gain, alopecia, Spina bifida (in babies)

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6
Q

Lamotrigine MOA

A

Blocks high frequency firing through Na channels

Interferes with glutamate release and activation of excitatory receptors

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7
Q

Lamotrigine indications

A

Second line for the 3 main types of seizures

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8
Q

Phenytoin side effects

A

Gum hyperplasia
Acne
Hirsutism

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9
Q

Carbamazepine MOA

A

Blocks sustained high frequency repetitive firing action potentials due to blockade of Na channels

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Pharmacology (6 decks)

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