Sedative/Anesthetic/Tranquilizer

Question 1

Acepromazine Maleate

Answer 1

• Tranquilizer (phenothiazine tranquilizer)
• MOA: phenothiazine tranquilizer which inhibits central dopaminerigic receptors to cause sedation/tranquilization. Antimuscarinic action and blocks norepinephrine at adrenergic receptors (alpha-receptors).
• Tx: sedate, anesthetic adjunct, antiemetic
• SE: sedation, ataxia, hypotention (due to alpha adrenergic antagonism) +/- increased vagal tone (especially brachycephalic)

Papich

Question 2

Trazodone HCl

Answer 2

• Seratonin 2a antagonist/Reuptake Inhibitor
• MOA: Potentiates seratoning activity in the CNS
• Tx: behavioral disorders, anti-anxiety
• SE: sedation, ataxia, cardiac conduction disturbance. Serotonin syndrome possible if given withi other serotonergic drugs. *Do not give to patients on MAO inhibitors
• 2-5mg/kg upwards to 14mg/kg/day

Plumb (8th Ed)

Question 3

Alfaxalone

Answer 3

• Anesthetic
• MOA: neuroactive steroid moleculre with properties of a feneral anesthetic. Modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABA cell surface receptors. Metabolism by p450 and conjugation.
• Tx: anesthetic/sedative
• SE: respiratory depression/apnea
• Caution in patients with hepatic dysfunction
• 2-3mg/kg IV/IM (GA dosing)

Plumb (7th ed)