Antiparasitics

Question 1

Fenbendazole

Answer 1

• Antiparasitic
• Inhibits glucose uptake by the parasites, leading to energy depletion and death. Does not effect mammal glucose uptake
• Effective against helminth, nematodes
• SE: good saftey margins, uncommon GI, rare report of pancytopenia
• 50mg/kg/day PO x 3-5 days

Papich

Question 2

Metronidazole Benzoate

Answer 2

• Antibacterial (anaerobic), Antiparasitic (protozoal)
• Second generation nitroimidazole. Generation of free nitrordicals via metabolism within organism. Disrupts DNA via reaction with intracellular metabolite. May have some immune-modulating activity in instetines of animals being treated for IBD
• Tx: diarrhea + GI protozoa + anareoic infections
• SE: toxicity to CNS (often high doses, >60 mg/kg/day)- ataxia, tremors seizures- due to inhibition of action of GABA. GI upset.

Papich