Analgesic

Question 1

Gabapentin

Answer 1

• Anticonvulsant, Analgesic
• MOA uncertain/unclear- analog of the inhibitory neurotransmitter GABA. May bind to voltage-sensative calcium changels in neuronal tisse and inhibit administration. Renal clearance (30% liver in dogs)
• SE: sedation, ataxia. Careful with xylitol sweeter. Antiacids will decrease oral absorption.
• 30-60mg/kg/day

Papich/Rushing

Question 2

Tramadol

Answer 2

• Analgesic
• MOA: some mu-opioid receptior action, may inhibit reuptake of norepinephrine (NE) or serotonin (5 HT). The metabolite (desmethltramadol, called M1) may have greater opioid effects.
• SE: Sedation. May potentiate the effects of other CNS depressant medications (opioids, alpha 2 agonists, SSRIs).

Papich

Question 3

Butorphanol

Answer 3

• Analgesic, Opioid
• MOA: Kappa receptor agonist and weak mu receptor antagonist (or parital agonist). Short duration.
• Tx: weak analgesic. Antitussive agent
• SE: sedation, respiratory depression (high doses), dysphria, GI ileus
• Max 0.8mg/kg (above this is no effect)
• Reversal: naloxone

Papich