Section 3 - Organisms exchange substances with their environment: 7. Mass transport Flashcards
What is a Haemoglobin molecule
A Globular protein within red blood cells, that transports oxygen within the bloodstream
What is the structure of Haemoglobin
- 4 polypeptides linked together (quaternary structure)
- Each polypeptide is associated with a haem group, containing an Fe^2+ ion.
How many O2 molecules can bind to one Haemoglobin molecule
4
(each Fe^2+ binds to one O2 molecule)
What is oxygen loading/association and where does it occur
Process where Haemoglobin binds with O2
(In humans, occurs in the lungs)
What is oxygen unloading/dissociation and where does it occur
Process where Haemoglobin releases O2
(In humans, occurs near the tissues/muscles cells)
What is shown on an oxygen dissociation curve
Plot of Haemoglobin saturation (%) against partial pressure of oxygen (KPa)
What is meant by the Haemoglobin’s affinity for oxygen
Determines how easily it takes in/gives out O2
- Changes in different conditions within the body
- Different organisms are adapted to have different affinities
What is the shape of an oxygen dissociation curve.
Sigmoid shape (starts shallow, gets steeper, finishes shallow)
What does the position of the oxygen dissociation curve determine about the affinity
- Line further to the left = Greater affinity (loads readily, harder to unload)
- Line further to the right = Lower affinity (more difficult to load, but readily unloads)
What is the process of cooperative binding (of Haemoglobin and O2)
1) Due to the shape of the binding site of haemoglobin, it is difficult for the first O2 to attach, so the initial rate of association is low.
2) After the first has attached, it is easier for the second to bind as the shape has changed, so the rate of association increases.
3) Once 2 are attached, it is still easier for the third to bind as the shape has changed, but there is now only a 50% chance that the site an O2 collides with is empty, so the rate of association decreases.
4) Now there is only one empty binding site, so a 25% chance that the O2 collides with a site it can bind to, so the rate of association decreases further as the haemoglobin saturation approaches 100%
What is the effect of CO2 on affinity
Increased CO2 causes and increase in blood acidity, lowering the pH and effecting the ionic bonds in the haemoglobin’s tertiary structure, changing its shape, so decreasing its affinity for O2
What is the Bohr effect and how does it allow for different haemoglobin affinities within the body.
- In areas of high O2 and low CO2 concentration (such as the lungs), the haemoglobin’s affinity increases to take in more O2
- In areas of low O2 and high CO2 concentration (such as near the muscle tissue after respiration), the haemoglobin’s affinity decreases, unloading the O2, so it can be used by the cells.
What factors effect the affinity of haemoglobin at regular CO2 levels
- Environment
- Organism size
- Activity level
All impact metabolic rate (and respiratory rate), so alter the CO2 conc. near cells, changing the haemoglobin affinity
Why do large organisms have specialised transport systems
Diffusion alone isn’t efficient enough to exchange materials of large distances (increased size = decrease SA:Vol)
What are the main features of a mass transport system
- Medium to carry materials (eg. blood, air, etc.)
- A closed system of vessels to distribute the medium around the organism
- A mechanism for moving the transport medium (pressure difference), such as muscle contractions, evaporation, etc
- A mechanism to maintain unidirectional flow (eg. valves)
- A way to control the flow for different needs in different areas (eg. Arteries –> Capillaries –> Veins)
What is a double circulatory system
Blood passes through the heart twice in each cycle
Why is a double circulatory system required in mammals
Travelling through the capillaries in the lungs reduces the blood pressure, so it must return the the heart before being circulated to the rest of the body
What is the structure of the human heart
2 pumps side by side, with the left (–>) containing oxygenated blood, and the right (<–) containing deoxygenated blood.
What is the structure and function of the atrium
Thin walled and elastic, collects blood into the heart
What is the structure and function of the ventricle
Thick, muscular wall that contracts to increase blood pressure, pumping blood out of the heart
What are the values between the atria and ventricles
- Right (<–) atrioventricular value = Tricuspid valve
- Left (–>) atrioventricular valve = Bicuspid valve
What is the function of the Pulmonary artery
Carries deoxygenated blood from the heart to the lungs
What is the function of the Pulmonary vein
Carries oxygenated blood from the lungs to the heart
What is the function of the Aorta
Carries oxygenated blood out of the heart to the rest of the body
What is the function of the Vena Cava
Carries deoxygenated blood back to the heart from the rest of the body
What is the function of the coronary artery
Carries oxygenated blood to the muscle of the heart (branches off of the Aorta)
What is a Cardiovascular disease
Disease that affects the heart or blood vessels (such as coronary heart disease)
What are the risk factors for cardiovascular diseases
- Smoking
- High blood pressure
- Blood cholesterol
- Diet
How will smoking increase the risk of cardiovascular diseases
- Carbon monoxide binds with haemoglobin irreversibly, preventing O2 from binding, reducing blood oxygen saturation
- Nicotine produces adrenaline, increasing heart rate, so increasing blood pressure.
- Can cause platelets to become sticky
How will high blood pressure increase the risk of cardiovascular diseases
- The heart has to work harder to pump the blood, so is prone to failure
- Can cause an aneurysm, resulting in blood vessels bursting