Section 3: Hemodynamic Disorders Flashcards
Hemostasis
Process which causes bleeding to stop
Keeps blood in a damaged blood vessel
Increased blood volume can be due to ___ or ___
Hyperemia
Congestion
Congestion is a ___ process
Passive
Venous obstruction can lead to ___ (bluish color)
Cyanosis
Congestion can be caused by
Congestive Heart Failure
Deep Vein Thrombosis
Chronic pulmonary congestion causes fibrotic
Alveolar septa
Heart failure cells are composted of
Macrophages
Hemosiderin
Heart failure cells are found in
Chronic pulmonary congestion
In lungs after heart failure
Congestive hepatopathy can be caused by anything that obstructs
Hepatic venous drainage
Necrosis caused by congestive hepatopathy can cause
Nutmeg liver
Centrilobular necrosis
Central lobule of liver dying due to congestive hepatopathy
Edema
Abnormal accumulation of interstitial fluid
2/3 of body’s H2O is
Intracellular fluid
1/3 of body’s H2O is
Interstitial fluid
Interstitial fluid is drained by
Lymphatics
2 types of edema
- Localized (MC)
2. Generalized (rare)
Types of localized edema
- Lower extremities
- Peritoneal cavity
- Pleural cavity
Edema in peritoneal cavity can be called
Ascites
Ascites occurs due to occlusion of hepatic veins, which can occur due to
Cirrhosis
Cancer
Blood clots
Edema in pleural cavity can be called
Hydrothorax (fluid around lungs)
Generalized edema occurring in subcutaneous tissues can be called
Anasarca
Anasarca is bodywide edema due to
Low dietary protein
Edema can be caused by
- inflammation
- too much hydrostatic pressure
- too little osmotic pressure
- lymphatic obstruction
- retention of sodium or H2O
Increased hydrostatic pressure is from
Impaired venous return
Localized impaired venous return
Deep vein thrombosis
Generalized impaired venous return
Congestive heart failure
Reduced osmotic pressure can be from
Too few plasma proteins
Hypoalbuminemia
Most common plasma protein
Albumin
Too few plasma proteins can be due to
Reduced production of proteins
Increased loss of proteins
Increased loss of plasma proteins can be due to
Nephrotic syndrome
Nephrotic Syndrome
Peripheral edema
Proteinuria
Hyperlipidemia
Hypoalbuminemia
Lymphatic obstruction can occur due to
Inflammation / fibrosis
Tumors
Inactivity
Damage to which organs are most likely to be involved with edema
Liver
Heart
Kidney
Filariasis aka
Elephantiasis
Filariasis caused by
Extreme lymphatic obstruction due to bacterial infection
A mastectomy can cause ___ due to scar tissue obstructing lymph drainage
Lymphedema
Peau d’orange
Tethering of sweat glands of the breast due to edema pushing upward
Due to severe lymphatic obstruction
Causes of sodium and water retention
A. High salt diet
B. Hypoperfusion to kidneys
C. Acute renal failure
D. Poststreptococcal glomerulonephritis
Increased water volume causes increased
Pressure
Exudate
Protein rich edema
Dependent edema
Ankles or sacrum (pressure ulceration)
Cerebral edema
Increased intracranial pressure
Cerebral edema can be caused by
Abnormal BBB (tumors, infection, trauma)
Cell membrane injury (toxins, hypoxia)
Pitting edema
Transudate accumulates
Protein poor
No osmosis
Non-inflammatory
Ex. Heart Failure
Non-Pitting Edema
Exudate accumulates
Protein rich
Osmosis
Inflammatory
Hemorrhage
Extravasation of blood from vessels
Hypovolemic shock
Rapid loss of greater or equal 20% of blood volume
Hematoma
Large accumulation of blood within tissue
Contusion
Trauma causing bruise (hematoma)
Ecchymosis
Minor trauma
Hematoma from unlikely trauma
Petechiae
Small area of hemorrhage (1-2mm)
Common cause of petechiae
Low platelets
Vit K deficiency
Vit C deficiency causing vessel fragility
Purpura
Slightly larger hemorrhage (3-5 mm)
Common causes of purpura
Mechanical trauma
Vasculitis
Vessel fragility from Vit C deficiency
Progressive change of color in contusions
Red/blue —green— yellow
Transition of color in contusions is due to hemoglobin broken down to ___ and ____
Bilirubin
Hemosiderin
3 main components of normal hemostasis
Platelets
Endothelium
Coagulation cascade
Primary hemostasis occurs when ___ aggregate on vessel wall following endothelial damage
Platelets
Endothelial Damage exposes sub-endothelial ___ and ___ to contents of blood, activating platelets to form ___
Von Willebrand factor (vWF)
Collagen
Primary plug
Secondary hemostasis involved formation of
Fibrin-rich clot
Endothelium normal ____ thrombosis
Inhibits
Injury to vascular endothelia exposes _____
Tissue factor
Thrombin cleaves ____ into ___
Fibrinogen
Fibrin
Coagulation cascade activates
Thrombin
____ (in bone marrow) produce platelets
Megakaryocytes
Virchow’s Triad
Endothelial injury
Hypercoagulability
Abnormal blood flow
Endothelial activation
Normal anti-thrombotic endothelia become pro-thrombotic
Stimuli that may cause endothelial injury
Atherosclerotic plaques Inflammation Abnormal blood flow Hypercholesterolemia Toxic exposure
Aspirin is an ___ drug
Antiplatelet
Warfarin and heparin are ___ drugs
Anticoagulants
Abnormal blood flow promotes
Endothelial activation
Excessively viscous blood results in stasis, which makes the blood prone to
Clotting
Polycythemia
Increased RBC
Highly viscous blood may be caused by
Polycythemia
Sickle cell disease
Mutations that may cause hyper-coagulability
Factor V
Prothrombin
4 fates of a thrombus
Dissolve
Enlarge
Embolize
Organization
Features of a venous thrombus
Congestion
Tenderness
Pitting edema
Features of arterial thrombus
Cell injury
Inflammation
Infarction
Venous thrombosis grows ____ venous blood flow
Along with
Anterograde
Venous thrombi begins at site of
Stasis
Common locations of venous thrombi
Popliteal or femoral
90% of venous thrombi occur in
Lower extremities (DVT)
Arterial thrombi grow ___ arterial blood flow
Against
Retrograde
Arterial thrombi begins at
Site of injury/ turbulence
Common locations of arterial thrombi
Coronary
Cerebral
Femoral
All thrombi roads lead to the
Heart
Lines of Zahn
Microscopic light and dark layers of a thrombus due to platelets and RBCs at a site of high blood pressure
For lines of Zahn to form, the patient must be
Alive when the clot formed
Disseminated Intravascular Coagulation (DIC)
Widespread thrombosis/ coagulopathy
Complication of severe trauma
Widespread organ failure
Embolism
When a detached intravascular mass (embolus) becomes lodged in a vessel
Types of emboli
Solid
Liquid
Gas
Ex of solid emboli
Thrombus, fat, plaque
Ex of liquid emboli
Amniotic fluid
Ex of gas emboli
Air
Nitrogen (Caisson Disease)
Pulmonary embolism occurs due to
Occlusion of pulmonary artery
____ of PE are recurrent
30%
___ of PE originate from DVTs
95%
____ of PE are small and clinically silent
80%
___ of PE are massive and fatal
2%
Tachypnea
> 20 BPM
Systemic thromboembolism occurs within the
Arterial system
Paradoxical embolism
Crosses from venous to arterial system
For someone to have a paradoxical embolism, there must be either _____ or ____
Atrial septal defect
Ventricular septal defect
Infarction
Death of tissue, due to obstructed blood supply
Red (hemorrhagic) infarction occurs in lungs due to
Natural cavities and dual blood supply
White (pale/anemic) infarction occurs in
Solid walled organs
Shock
Inadequate blood supply (perfusion) to tissues, resulting in cellular injury dysfunction and possibly death
Types of shock with peripheral vasoconstriction and SNS activation
- Cardiogenic
2. Hypovolemic
Cardiogenic shock occurs due to
Pump failure —decreased output
Hypovolemic shock occurs due to
Loss of blood/plasma volume
Types of sock with peripheral vasodilation
- Septic
- Neurogenic
- Anaphylactic
Septic shock
Systemic immune reaction
Neurogenic shock
<60 BPM
CNS trauma
Anaphylactic shock
Severe allergy
Vasovagal syncope
Decreased HR
Decreased BP
Lightheaded
Vision problems
Stages of shock
- Nonprogressive
SNS compensatory mechanisms - Progressive
Widespread hypoperfusion - Irreversible
Widespread membrane damage