Exam 1 Remaining Material Flashcards
Granuloma
Collection of macrophages
Granuloma AKA
Epithelioid cells
Giant cells
Caseating Granuloma indicates
TB
Inflammatory mediators
Prostaglandins
Substance P
Prostaglandins
Pain
Fever >100.4 F/ 38C
Substance P
NT
Pain signals
Unresolved inflammatory reactions can be caused by
Persistent infection
Immunosuppression
Hypersensitivity reactions
Features of chronic inflammation
Mononuclear WBC (macrophages, lymphocytes, plasma cells)
Tissue destruction
Vessel production and fibrosis
Lymphocytes are a part of
Innate and adaptive immunity
B Cells evolve into ___ that secrete ___
Plasma cells
Antibodies
Lymphocytes sustain
Chronic inflammation via cytokines
Dominant cell type at site of chronic inflammation
Macrophages
Job of macrophages
Phagocytosis of microbes and injured cells
Initiate angiogenesis and fibrosis
Classically activated macrophages
- Phagocytosis and killing
2. Inflammation
Alternatively activated macrophages
- Tissue repair, fibrosis
2. Anti-inflammatory effects
Alternatively activated macrophages secrete GFs that promote
Fibroblasts- scarring
Angiogenesis
Systemic effects of inflammation initiated by
Cytokines
Steps fo scar formation
- Angiogenesis
- Fibroblast migration and proliferation
- Collagen deposition
- Remodeling
Granulation tissue develops in ___ days
3-5
Fibrosis occurs when
- severe damage
- prolonged injury
- injury to terminally differentiated cells