Section 2b Adrenergic Agonists Flashcards
what amino acid is DOPA made from?
Tyrosine
What part of the catecholamine biosynthesis happens in the cytoplasm?
Tyrosine –> DOPA –> Dopamine
Where does the majority (~90%) of catecholamines (NE) come from?
Presynaptic (re)uptake via NET
what blocks catecholamine synthesis?
methyltyrosine
what blocks catecholamine storage?
reserpine via VMAT - release empty vesicles
what increases catecholamine release?
tyramine, amphetamine (indirect action)
what blocks catechol. release?
guanethidine
what blocks chatechol. (re) uptake presynaptically?
cocaine, tricyclic antidepressants via NET (indirect action)
what blocks chatechol. metabolism?
MAO inhibitors
Where are VMAT 1 and 2 found?
1 = peripheral 2 = CNS
What is a NET selective blocker?
Atomoxetine - treatment of ADHD
what has a mixed (direct and indirect) adrenergic agonist action?
ephedrine
What is the preference of Epi vs NE for B1 and B2?
B1 - Epi=NE
B2 - Epi>NE
What is the preference of Epi, NE, and Iso for a receptor?
Epi > NE > Iso
What is the preference of Epi, NE, and Iso for B receptor?
Iso > Epi > NE