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Pharmacology 1 > Section 2a (NTs and locations, etc) > Flashcards

Section 2a (NTs and locations, etc) Flashcards

1
Q

Other ANS transmitters (non-adrenergic and non-cholinergic transmission) (7)

A

ATP, CGRP, neuropeptide Y, 5HT, Substance P, VIP, and NO

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2
Q

What Muscarinic receptor(s) increase IP3 and DAG thus increase intracellular Ca2+ = contraction

A

M1, M3, M5

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3
Q

What are the 2 cholingergic receptors?

A

Muscarinic and Nicotinic

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4
Q

What muscarinic receptor(s) activate K+ channels and inhibit adenylyl cyclase = hyperpolarization (inhibits next signal)

A

M2, M4

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5
Q

How does the nicotinic receptor work?

A

sodium channel –> depolarization

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6
Q

What are the 2 types of nicotinic receptors?

A

muscle and neuronal type

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7
Q

What are the 2 adrenergic receptors?

A

Alpha and Beta

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8
Q

What does a1 do?

A

increase IP3 and DAG which increase Ca2+ = smooth muscle contraction

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9
Q

What does a2 do?

A

inhibit adenylyl cyclase and decreases Ca2+ conductance, and increases K+ conductance = hyperpolarization

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10
Q

What do all the B’s do?

A

Stimulate adenylyl cyclase = increase in cAMP

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11
Q

Which Dopaminergic receptor(s) increase cAMP?

A

D1, D5

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12
Q

Which Dopaminergic receptor(s) decrease cAMP and increase K+ conductance (hyperpolarization)

A

D2, D3, D4

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13
Q

What does NE do in the heart? and by what receptor?

A

increase heart rate, and contractility via B1 (B2)

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14
Q

What does ACh do in the heart? receptor?

A

decrease heart rate, and contractility via M2

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15
Q

What does NE do in the skin/splanchnic vessels? receptor?

A

vasoconstriction, a1

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16
Q

What does NE do in skeletal muscle? Receptors (s)?

A

vasodilation (B2) & vasoconstriction (a1)

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17
Q

What does ACh do in the endothelium? receptor?

A

vasodilation, M3 (sympathetic cholinergic)

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18
Q

What does NE do to Bronchiolar smooth muscle? Receptor?

A

Relaxation (Bronchodilation), B2

19
Q

NE to Bronchial glands, receptor?

A

decrease secretion, a1

20
Q

ACh to bronchiolar smooth muscle, receptor?

A

Contraction (Bronchoconstriction), M3

21
Q

ACh to bronchial glands, receptor?

A

increase secretion, M (any)

22
Q

NE to smooth muscle (logitudinal) in GI tract, receptor?

A

relaxation, a1, B2

23
Q

NE to sphincters in GI tract, receptor

A

contraction, a1

24
Q

NE to GI secretion, receptor?

A

inhibits secretion, a2

25
Q

ACh to smooth muscle (logitudinal) in GI tract, receptor?

A

contraction, M3

26
Q

ACh to sphincters, receptor?

A

relaxation, M3

27
Q

ACh to GI secretion, receptor?

A

increased secretion, M3

28
Q

NE on Urinary bladder effect(s)? receptor(s)?

A

Detrusor wall - relaxation (B2)

Sphincter - contraction (a1) - urinary continence

29
Q

ACh on Urinary bladder effect(s)? receptor(s)?

A

Detrusor wall - contraction (M3)

Sphincter - relaxation (M3)

30
Q

NE on Uterus (Pregnancy), receptor(s)?

A

a1 - contraction

B2 - relaxation

31
Q

NE on prostate, receptor?

A

a1 - contraction

32
Q

ACh on Uterus (Pregnancy), receptor?

A

M3 - contraction

33
Q

NE on radial muscle in Iris, receptor?

A

a1 - contraction (mydriasis) = pupil dilated

34
Q

ACh on circular muscle in Iris, receptor?

A

M3 - contraction (miosis) = pupil contracted

35
Q

NE on ciliary epithelium (affect secretion), receptor?

A

B - secretion of aqueous humor

36
Q

NE on ciliary muscle, receptor?

A

relaxation (far vision) - B

37
Q

ACh on ciliary muscle, receptor?

A

contraction (near vision) - M3

38
Q

NE on pilomotor smooth muscle, receptor?

A

contraction - a1

39
Q

NE on sweat glands, receptor?

A

apocrine - a1 - localized secretion (stress)

40
Q

ACh on sweat glands, receptor?

A

thermoregulatory - M - generalized secretion (Sympathetic cholinergic)

41
Q

NE on liver, receptors?

A

a1, B2 = glycogenolysis and gluconeogenesis

42
Q

NE on kidney, receptor?

A

B1 = renin release

43
Q

NE on pancreas, receptors?

A 
a1 = decrease insulin secretion
B2 = increase insulin secretion
44
Q

NE on adipose tissue, receptors?

A

B1, B3 = lipolysis

a2 = decrease lipolysis

Pharmacology 1 (10 decks)

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