Section 2a (NTs and locations, etc) Flashcards
Other ANS transmitters (non-adrenergic and non-cholinergic transmission) (7)
ATP, CGRP, neuropeptide Y, 5HT, Substance P, VIP, and NO
What Muscarinic receptor(s) increase IP3 and DAG thus increase intracellular Ca2+ = contraction
M1, M3, M5
What are the 2 cholingergic receptors?
Muscarinic and Nicotinic
What muscarinic receptor(s) activate K+ channels and inhibit adenylyl cyclase = hyperpolarization (inhibits next signal)
M2, M4
How does the nicotinic receptor work?
sodium channel –> depolarization
What are the 2 types of nicotinic receptors?
muscle and neuronal type
What are the 2 adrenergic receptors?
Alpha and Beta
What does a1 do?
increase IP3 and DAG which increase Ca2+ = smooth muscle contraction
What does a2 do?
inhibit adenylyl cyclase and decreases Ca2+ conductance, and increases K+ conductance = hyperpolarization
What do all the B’s do?
Stimulate adenylyl cyclase = increase in cAMP
Which Dopaminergic receptor(s) increase cAMP?
D1, D5
Which Dopaminergic receptor(s) decrease cAMP and increase K+ conductance (hyperpolarization)
D2, D3, D4
What does NE do in the heart? and by what receptor?
increase heart rate, and contractility via B1 (B2)
What does ACh do in the heart? receptor?
decrease heart rate, and contractility via M2
What does NE do in the skin/splanchnic vessels? receptor?
vasoconstriction, a1
What does NE do in skeletal muscle? Receptors (s)?
vasodilation (B2) & vasoconstriction (a1)
What does ACh do in the endothelium? receptor?
vasodilation, M3 (sympathetic cholinergic)
What does NE do to Bronchiolar smooth muscle? Receptor?
Relaxation (Bronchodilation), B2
NE to Bronchial glands, receptor?
decrease secretion, a1
ACh to bronchiolar smooth muscle, receptor?
Contraction (Bronchoconstriction), M3
ACh to bronchial glands, receptor?
increase secretion, M (any)
NE to smooth muscle (logitudinal) in GI tract, receptor?
relaxation, a1, B2
NE to sphincters in GI tract, receptor
contraction, a1
NE to GI secretion, receptor?
inhibits secretion, a2
ACh to smooth muscle (logitudinal) in GI tract, receptor?
contraction, M3
ACh to sphincters, receptor?
relaxation, M3
ACh to GI secretion, receptor?
increased secretion, M3
NE on Urinary bladder effect(s)? receptor(s)?
Detrusor wall - relaxation (B2)
Sphincter - contraction (a1) - urinary continence
ACh on Urinary bladder effect(s)? receptor(s)?
Detrusor wall - contraction (M3)
Sphincter - relaxation (M3)
NE on Uterus (Pregnancy), receptor(s)?
a1 - contraction
B2 - relaxation
NE on prostate, receptor?
a1 - contraction
ACh on Uterus (Pregnancy), receptor?
M3 - contraction
NE on radial muscle in Iris, receptor?
a1 - contraction (mydriasis) = pupil dilated
ACh on circular muscle in Iris, receptor?
M3 - contraction (miosis) = pupil contracted
NE on ciliary epithelium (affect secretion), receptor?
B - secretion of aqueous humor
NE on ciliary muscle, receptor?
relaxation (far vision) - B
ACh on ciliary muscle, receptor?
contraction (near vision) - M3
NE on pilomotor smooth muscle, receptor?
contraction - a1
NE on sweat glands, receptor?
apocrine - a1 - localized secretion (stress)
ACh on sweat glands, receptor?
thermoregulatory - M - generalized secretion (Sympathetic cholinergic)
NE on liver, receptors?
a1, B2 = glycogenolysis and gluconeogenesis
NE on kidney, receptor?
B1 = renin release
NE on pancreas, receptors?
a1 = decrease insulin secretion B2 = increase insulin secretion
NE on adipose tissue, receptors?
B1, B3 = lipolysis
a2 = decrease lipolysis
