Secondary hemostasis

Question 1

Where are coagulation factors made?

Answer 1

Produced in the liver (except for VII which is only partially made in the liver).
The RES of the liver helps to regulate coagulation and fibrinolysis by clearing these factors from circulation.

Question 2

State in which coagulation factors circulate in plasma

Answer 2

Inactive form

Question 3

After activation, coagulation factors are kept in check (or inactivated) by

Answer 3

specific inhibitors

Question 4

Final step of coagulation

Answer 4

conversion of fibrinogen to fibrin

Question 5

Extrinsic pathway

Answer 5

Initiated by TF
TF:VIIa complex converts FX to FXa
Factor VII is acted upon by TF

Question 6

Components of the extrinsic ten-ase complex

Answer 6

TF:VII + (Ca++) + PF3

Question 7

What initiates the intrinsic pathway?

Answer 7

Negatively charged phospholipids

Question 8

Components of the intrinsic ten-ase complex

Answer 8

FIX + FVIIIa + (Ca++) + PF3

Question 9

Common pathway activation

Answer 9

Initiated by activation of factor X to Xa. By either extrinsic or instrinsic

Question 10

Components of the prothrombinase complex

Answer 10

FXa + FVa + PF3 + (Ca++)

Question 11

Action of the prothrombinase complex

Answer 11

Converts prothrombin (II) to thrombin (IIa)

Question 12

Activity of thrombin

Answer 12

Converts fibrinogen (FI) to to fibrin monomers (Ia). Monomers polymerize end to end and associate

Question 13

Factor XIIIa role

Answer 13

cross-link fibrin monomers into an insoluble fibrin polymer (clot)

Question 14

Vitamin K dependent coagulation factors

Answer 14

II, VII, IX, X