Disorders of primary hemostasis

Question 1

Qualitative defects

Answer 1

involve platelet function

Question 1

Quantitative defects

Answer 1

Involve the number of circulating platelets

Question 2

How will a primary hemostatic abnormality generally appear in patients?

Answer 2

Bleeding because of defects in formation of the primary hemostatic platelet plug

Question 3

Acquired

Answer 3

Bleeding which presents in adulthood

Question 4

Congenital

Answer 4

bleeding episodes present during early childhood.

Question 5

Types of bleeding

Answer 5

Purpura
Easy bruisability
Excess bleeding

Question 6

Purpura

Answer 6

Purple spots on skin
Petichiae- pinpoint to small round red spots
Ecchymoses- discoloration from bleeding under the skin

Question 7

Excess bleeding involves

Answer 7

both platelet and coagulation abnormalities

Question 8

Deficient platelet production occurs in the following conditions

Answer 8

increased marrow cellularity such as seen in megaloblastic anemia, myelodysplastic syndromes and alcohol use
congenital megakaryocytic hypoplasia
Bernard-Soulier
neonatal thrombocytopenia
virus and chemotherapy drugs