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MTAP 2 - HEMA 2 > Secondary Hemostasis > Flashcards

Secondary Hemostasis Flashcards

1
Q

Secondary Hemostasis phases

A

Coagulation
Fibrin clot formation
Fibrin Stabilization

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2
Q

How many coagulation factors are involved

A

At least 16 procoagulants

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3
Q

Procoagulants are transported by

A

Plasma

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4
Q

Inactive form of enzymes

A

Zymogens (Procoagulant)

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5
Q

Zymogens are

A

PK
2,7,9,10,11,12,13

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6
Q

Binds, stabilized, enhance activity of respective enzymes

A

Cofactors

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7
Q

Cofactors are

A

Tissue factor, HMWK, V, VIII, Thrombomodulin, Protein Z and S

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8
Q

Serves as regulator for coagulation process

A

Control protein

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9
Q

Substrate for the enzymatic function of thrombin

A

Fibrinogen

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10
Q

Factor I is also known as

A

Fibrinogen

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11
Q

Factor II is also known as

A

Prothrombin

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12
Q

Factor III is also known as

A

Tissue thromboplastin (mixture of TF and Phospholipid)

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13
Q

Other term for FIII

A

Tissue Factor

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14
Q

FIV is also known as

A

Calcium

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15
Q

FV is

A

Proaccelerin

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16
Q

Other term for FV

A

Labile Factor, Ac globulin

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17
Q

FVI is

A

Activated form of FV

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18
Q

FVII is

A

Proconvertin

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19
Q

Other term for FVII

A

Stable Factor
SPCA (Serum Prothrombin Conversion Activator)

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20
Q

FVIII is also known as

A

Antihemophilic factor

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21
Q

Other term for VIII

A

AHG
Antihemophilic factor A

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22
Q

FIX

A

Plasma Thromboplastin Component

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23
Q

Other term for FIX

A

Christmas Factor
Antihemophilic Factor B

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24
Q

FX

A

Stuart Factor

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25
Q

Other Term for FX

A

Stuart-prower Factor

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26
Q

FXI

A

Plasma Thromboplastin Antecedent

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27
Q

Other term for FXI

A

Antihemophilic factor C

28
Q

XII

A

Hageman Factor

29
Q

Other term for XII

A

Glass or Contact Factor

30
Q

XIII

A

Fibrin Stabilizing Factor

31
Q

Other term for XIII

A

FSF

32
Q

HMWK

A

Fitzgerald Factor

33
Q

Prekallekrin

A

Fletcher factor

34
Q

FVIII related antigen

A

vWF

35
Q

Classification of Coagulation Factors is necessary for

A

Diagnosis for Coagulation Factors deficiencies
Mixing studies

36
Q

classification of coagulations are

A

Fibrinogen group
Prothrombin group
Contact group

37
Q

Fibrinogen Group are

A

FII, FV, FVIII, FXIII

38
Q

Characteristics of Fibrinogen Group

A

Absorbed (not seen in serum)
Calcium dependent
Vitamin K independent

39
Q

Prothrombin group are

A

FI, FVII, FIX, FX

40
Q

Prothrombin group characteritics

A

Absordable and affected by COUMADIN
Calcium and Vitamin K dependent
Inhibited by warfarin

41
Q

Contact Group are

A

XI,XII, PK, HMWK

42
Q

Characteristics of Contact group

A

Not absorbed (seen in serum)
Calcium and Vitamin K INDEPENDENT
Involved in Coagulation Pathway

43
Q

Reaction begins with FXII

A

Intrinsic Pathway

44
Q

Primary step in Coagulation process

A

activation of XII

45
Q

Complex formed in intrinsic pathway that is necessary for activation of FX

A

IXa : VIIIa

46
Q

All factors in intrinsic pathway cause bleeding EXCEPT

A

FVII

47
Q

Test involved in Intrinsic pathway

A

PT, APTT (measures XII, XI, IX, VIII)

48
Q

Primary IN VIVIO inititation mechanism

A

TF:VIIa

49
Q

Laboratry test for extrinsic pathway

A

PT

50
Q

2 phases of coagulation

A

Initiation
Propagation

51
Q

Occurs on tissue factor expressing cells

A

Initiation

52
Q

Percentage of thrombin formed in INITIATION

A

3-5%

53
Q

Coagulation phase occurs in SURFACE OF PLATELETS

A

Propagation

54
Q

Percentage of Prothrombin formed in PROPAGATION

A

95%

55
Q

Extrinsic tenase complex that produces Small amount of FACTOR 2,9,10 (activated)

A

Initiation

56
Q

1-2% present in blood in actuvated form; to be activated by TF

A

FVIIa

57
Q

Provide TISSUE FACTOR

A

Fibroblast, Sub-endothelial cells

58
Q

Cofactor of VIIa

A

TF

59
Q

Activates low level of of FIX and FX

A

TF:VIIa

60
Q

Platelets in propagation phase are activated through

A

Low level of thrombin in initiation phase
Adhesion to exposed collagen

61
Q

Cofactors VIIIa and Va are activated by

A

Thrombin

62
Q

Generated by Initiation phase, intrinsic tenase complex

A

Factor IXa

63
Q

Prothrombinase complex are

A

Xa:Va

64
Q

Activates prothrombin = burst of Thrombin (95% or more)

A

Prothrombinase complex ( Xa:Va )

65
Q

Thrombin (IIa) action

A

Cleaves fibrinogen to form fibrin clot
Activates XIII to stabilize clot
Binds to thrombomodulin to activae Protein C control pathway
Activates TAFI

MTAP 2 - HEMA 2 (4 decks)

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