FIBRINOLYSIS

Question 1

Final stage of hemostatic activation

Answer 1

Fibrinolysis

Question 2

What happens in Fibrinolysis

Answer 2

Fibrin degradation
Restoring of blood flow
Hydrolysis of FIBRIN AND PLASMIN

Question 3

2 activators of Fibrinolysis

Answer 3

Tissue Plasminogen Activator (TPA)
Urokinase Plasminogen Activator (UPA)

Question 4

Inactive form of Plasmin

Answer 4

Plasminogen

Question 5

Plasmin breaksdown

Answer 5

Fibrinogen
Stable fibrin clot

Question 6

Degradation of fibrinogen and stable fibrin clot forms

Answer 6

Fibrinogen Monomer Degradation Product
Cross-linked Degradation Product

Question 7

Intrinsic Plasminogen Activator ; Produced by Urinary tract epithelial cells, monocytes and macrophage

Answer 7

UPA

Question 8

D-E-D ; (-) peptides; cleaved by Plasmin

Answer 8

Fragment X

Question 9

D-E (D&E)

Answer 9

Fragment Y

Question 10

Digestion of FIBRIN/FIBRINOGEN forms

Answer 10

Fragment XYDE

Question 11

Two D-Domains with separate fibrin molecules; CROSSLINKED OF XIIIa

Answer 11

Fragment D-D (D-dimer)

Question 12

Marker for THROMBUS AND FIBRINOLYSIS

Answer 12

D-Dimer

Question 13

INHIBITORS OF FIBRINLYSIS ARE

Answer 13

PAI-I (Plasminogen Activator Inhibitor-1)
A2-antiplasmin
TAFI (Thrombin Activatable Fibrinolysis Inhibitor)

Question 14

Principal inhibitor; Inactivates TPA and UPA

Answer 14

PAI-1

Question 15

Primary inhibitor of FRE PLASMIN (small amount of plasmin found in blood)

Answer 15

a2-antiplasmin

Question 16

Activated by THROMBIN-THROMBOMODULIN COMPLEX

Answer 16

TAFI

Question 17

Primary anti-fibrinolytic enzyme

Answer 17

TAFI

Question 18

A2-antiplasmin and TAFI are synthesized in

Answer 18

LIVER