Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GYN > Secondary Amenorrhea > Flashcards

Secondary Amenorrhea Flashcards

1
Q

Gold standard to test for Cushing syndrome?

A

24 hour urinary free cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q 
Amenorrhea
Acne
Hirsutism
Clitoromegaly
Deeping of voice
A

Sertoli-Leydig Tumore

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Rotterdam Criteria - what are they and how many do you need?

A

You need 2

  • menstural dysfunction (< 9 per year)
  • Hyperandrogenism (clinical signs or lab evidence)
  • US w/ polycystic ovaries (12 or more antral follicles measuring 2-9 mm)

“string of pearls”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Treatment for prolactinoma?

A

Dopamine Agonist)

Caberagoline and bromocriptine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Can you diagnose PCOS within 2 years of puberty?

A

NOPE!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Describe pathogenesis of PCOS

A

chronically elevated LH and insulin levels lead to increased androgen production with-in the ovarian theca

Hyperinsulinemia suppresses hepatic production of sex hormone binding globulin, which results in increased levels of free testosterone

Usually low levels of androgens increase aromatase activity within the follicle, but levels that are too high lead to follicular atresia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Chronic conditions linked to PCOS?

A 
T2DM
OSA
HLD
Metabolic Syndrome
NAFLD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Increased risk of T2DM in women > 30 yo w/ PCOS?

A

12% increased risk (2-5 fold)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

DHEAS is almost exclusively produced by what organ?

A

Adrenal glands

Extremely high levels (> 700) require additional work up and is suggestive of a hormone secreting adrenal tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What amount of weight loss will help improve symptoms of PCOS?

A

5% of initial body weight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How to OCPS work to treat PCOS?

A
  • Suppression of LH secretion
  • Suppression of ovarian androgen secretion
  • Increase sex hormone binding globulin circulating > decreases free testosterone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Criteria for metabolic syndrome?

A 
BP > 130/85
BG > 100
HDL < 50
TG > 150
Waist > 88 cm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

FDA approved treatment for Hirsutism?

A

Eflornithine

Eflornithine is an inhibitor of ornithine decarboxylase, which is an important enzyme related to hair growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does spironolactone work for treatment of hirsutism?

A

K Sparing diuretic

  • inhibiting steroidogenesis in the ovary and adrenal gland
  • Competing for the androgen receptor in the hair follicle
  • Directly inhibiting 5-alpha reductase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the best ovulation induction agent for someone with PCOS?

A

Letrazole (aromatase inhibitor)

  • Increased ovulation rates
  • Increased clinical pregnancy rates
  • Increased live birth rates

compared to clomid

*Although not FDA approved

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What cells in the ovaries produce androgens?

A

Theca cells

17
Q

US criteria for PCOS?

A

12 or more antral follicles (2-9 mm)

“string of pearls”

Ovarian volume 10 cm^3 or greater

GYN (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions