Breast Flashcards

1
Q

Women’s lifetime risk of developing caner?

A

12%

1 in 8 women

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2
Q

Recommend imaging for a breast mass in woman < 30?

A

Ultrasound

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3
Q

Imaging for breast mass in woman > 30?

A

Mammogram

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4
Q

BI RADS 0

A

No enough info

Get additional info

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5
Q

BI RADS 1

A

Negative

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6
Q

BI RADS 2

A

Benign (simple cyst)

Continue routine screening

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7
Q

BI RADS 3

A

Probably benign

CBE and US +/- mammogram for stability (if low suspicion) OR tissue biopsy (if high suspicion)

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8
Q

BI RADS 4

A

Suspicious

GET BIOPSY

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9
Q

BI RADS 5

A

Highly suggestive of malignancy

GET BIOPSY

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10
Q

When should women get screening mammograms?

A

Annually starting at age 40

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11
Q

Blood, serous or clear discharge is concerning for what?

A

Intraductal papillomas

If atypia present on core biopsy, need surgical excision since invasive or in situ carcinoma found in 15-20%

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12
Q

Most common cause of bloody nipple discharge?

A

Intraductal papillomas

If atypia present on core biopsy, need surgical excision since invasive or in situ carcinoma found in 15-20%

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13
Q

Most common benign tumor in the breast that accounts for half of all breast biopsies?

A

Fibroadenoma

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14
Q

Well defined, 1-2 cm, mobile mass on exam is likely what?

A

Fibroadenoma

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15
Q

Two most common pathogens in mastitis

A

Staph aureus

Strep Viridans

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16
Q

Treatment of breast abscess

A

I&D

If tissue is fluctuant OR if patient’s symptoms do not improve after 2-3 days of treatment

Send fluid for culture

Give IV antibiotics w/ Vanc until surgical I&D, then Bactrim DS BID for 10-14 days

17
Q

What hormone stimulates glandular growth in the breast?

A

Progesterone secreted by the theca EXTERNA

*overstimulation of these glands can lead to cyst formation, which in turns lead to fibrocystic change of the breast

18
Q

What is the risk of an underlying carcinoma in the surrounding areas of atypical ductal hyperplasia?

A

30%

Relative risk = 5.0

19
Q

Lifetime risk of ovarian cancer w/ BRCA1?

A

40%

20
Q

BRCA1 is found on what chromosome?

A

17

21
Q

BRAC2 is found on what chromsome?

A

13

22
Q

Performing elective oophorectomy at time of hysterectomy in premenopausal pt w/ no family or personal hx of cancer will increase her risk for???

A

All cause mortality

23
Q

Most likely clinical symptom of Paget’s disease of the breast?

A

Scaly rash arising from the nipple

24
Q

When is a breast MRI indicated for screening?

A

A high lifetime risk of breast cancer (>20-25%) = BRCA mutation carriers, strong family hx, or hx of chest radiation

25
Q

Treatment of DCIS?

A

Lumpectomy/WLE w/ or w/out radiation therapy

26
Q

When would you do a total mastectomy for treatment of DCIS?

A
  • Persistent positive margins
  • Multicentric disease involving more than one quadrant
  • Cosmetically unacceptable breast conservation surgery due to a large DCIS process

Li Fraumeni Syndrome
Cowden Syndrome
Peutz-Jeghers Syndrome

27
Q

What treatment is appropriate for a patient with a history of breast cancer and vasomotor symptoms of menopause?

A

Paroxetine

FDA APPROVED!

28
Q

Describe benign nipple discharge

A

Multiductal
Bilateral
Expressed
Green/Milky/Clear

29
Q

Descrbie malignant nipple discharge

A

Uniductal
Unilateral
Sponatneous
Serous/Clear/Bloody

30
Q

Nipple discharge w/ age > 40?

A

Requires US AND MAMMO regardless if benign or malignant features

31
Q

Endocrine therapy for pre menopausal breast ca?

A

Tamoxifen for 5 years

32
Q

Tamoxifen will decrease annual risk of breast cancer recurrence by how much?

A

40%!!

And reduces annual mortality by 35%!

33
Q

Endocrine therapy for post menopausal breast ca?

A

Tamoxifen OR Aromatse Inhibitor

*Aromatse inhibitors are more effective, and have a better SE profile

34
Q

Benefits of Aromatse inhibitors over tamoxifen?

A
  • reduced risk of thrombus
  • reduced em ca
  • reduced vaginal bleeding