Second Generation Antipsychotics

Question 1

Why are they known as Atypical Anti-psychotics?

Answer 1

Broader spectrum of action

Controlling both positive and negative symptoms of schizophrenia

Question 2

Why are they viewed as better than conventional antipsychotics?

Answer 2

Cause less severe EPS side effects

Not cardiotoxic

Question 3

What is their mechanism of action?

Answer 3

Largely unknown but thought to affect block different receptors in brain.
Thought mainly to act on D2 receptors (but only loosely bound).
Also thought to block serotonin and alpha-adrenergic receptors

Question 4

By taking these class of drugs it is thought to increase the risk of what?

Answer 4

Weight gain
Diabetes
Hypertriglyceridaemia

Question 5

What are the serious adverse effects related to this class of drugs?

Answer 5

Agranulocytosis
Orthostatic hypotension
Neuroleptic malignant syndrom

Question 6

What are the common side effects associated with this drug class?

Answer 6

Tachycardia, transient fever, sedation, dizziness, headache, light headedness, somnolence, anxiety, nervousness, hostility, insomnia, nausea, dry mouth, vomiting, constipation, secondary parkinsonism, Akathisia, EPS