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Mental Health Medications > First Generation Antipsychotics > Flashcards

First Generation Antipsychotics Flashcards

1
Q

Four Dopamine Pathways

A

Mesocorticol
Mesolimbic
Nigrostriatal
Tuberoinfundibular

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2
Q

Alternative Names for FGAs

A

Typical Antipsychotics
Neuroleptics
Dopamine Antagonists

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3
Q

Symptoms of Neurolepsis Syndrome

A

Psychomotor slowing
Emotional Quieting
Affective indifference

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4
Q

Which receptors do FGAs have a higher affinity for?

A

D2 receptors

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5
Q

What is the most common class of FGAs

A

Phenothiazines

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6
Q

Which dopamine pathway is associated with EPS

A

Nigrostriatal Pathway

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7
Q

What hormone (involved in milk production) is inhibited by Dopamine?

A

Prolactin

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8
Q

Which dopamine pathway is associated with the FGA side effect of hyperprolactinemia?

A

Tuberoinfundibular pathway

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9
Q

Why is blockade of D2 Receptors in nigrostriatal pathway associated with EPS?

A

Because this pathway is involved in production of movement.

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10
Q

What system involved in movement is the nigrostriatal pathway a part of?

A

Basal ganglia motor loop system.

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11
Q

Common side effects of antipsychotics?

E-PACCHA

A 
EPS
Psychic side effects
Anticholinergic 
Cardiovascular
Cardio-metabolic
Hormonal
Allergic reactions
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12
Q

EPS side effects commonly associated with Antipsychotics?

A

Muscle Stiffness

Shakiness

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13
Q

Anticholinergic side effects associated with Antipsychotics?

A

Dry mouth

Blurred Vision

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14
Q

Psychic side effects associated with antipsychotics?

A

Tiredness

Sedation

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15
Q

Cardiovascular side effects associated with antipsychotics?

A

Fast pulse

Q-T elongation

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16
Q

Allergic reaction side effects associated with antipsychotics?

A

Rashes

Unusual skin pigmentation

17
Q

Cardio-metabolic side effects associated with antipsychotics?

A

Weight gain
Insulin resistance
Metabolic syndrome

18
Q

Why do FGAs cause so many side effects?

A

They are not selective for any of the four dopamine pathways

19
Q

According to the BNF what are the names of the different derrivatives of FGAs?

A 
Phenothiazines
Butyrophenones
Thioxanthenes
Diphenylbutylpiperidines
Substituted benzamides
20
Q

How many sub-groups of Phenothiazines are there according to the BNF?

A

Three

21
Q

What are the main drugs in Group 1 Phenothiazines?

A

Chlorpromazine hydrochloride
levomepromazine
Promazine hydrochloride

22
Q

What are the effects/side effects associated with Group 1 Phenothiazines?

A

Pronounced sedative effect
Moderate anti-muscarinic effects
EPS

23
Q

What are the main drugs in Group 2 Phenothiazines?

A

Pericyazine

Mesoridazine

24
Q

What are the effects/side effects associated with Group 2 Phenothiazines?

A

moderate side effects

Fewer EPS than Group 1 & 3

25
Q

What are the main drugs in Group 3 Phenothiazines?

A

Fluphenazine
Perphenazine
Trifluoperazine

26
Q

What are the effects/side effects associated with Group 3 Phenothiazines?

A

Fewer sedative and anti-muscarinic effects

More pronounced EPS than Group 1 & 2

27
Q

What are the main drugs in the Butylphenones derrivatives?

A

Haloperidol

Benperidol

28
Q

What are the effects/side effects of the Butylphenones ?

A

Resemble Group 3 of Phenothiazines

29
Q

What are the main drugs in the Thioxanthenes

derrivatives?

A

Flupentixol

Zuclopenthixol

30
Q

What are the effects/side effects of the Thioxanthenes?

A

Moderate sedative effects
Moderate anti-muscarinic effects
Moderate EPS

Mental Health Medications (12 decks)

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