SCREENING Flashcards

1
Q

Screening is The early detection of:

A

Disease
● Precursors of disease
● Susceptibility to disease

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2
Q

The presumptive identification of those who probably have the disease from those who do not have the disease by means of rapidly applied tests in apparently healthy individuals (WHO).

A

screening

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3
Q

Iceberg of Disease

A

Only the symptomatic cases are visible. Carriers are considered as invisible cases.

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3
Q

detection of disease precursors of disease as a guide to the medical care
of individuals.

A

Prescriptive Screening

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4
Q

attacks a more broader population. all population

A

prospective screening

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5
Q

Uses of screening

A

Case Detection- Prescriptive Screening (Person’s benefit)
Case or Disease Control- Prospective Screening (Benefit of others)
Research- Natural History of Disease
Health Education- Public Awareness

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6
Q

Compare screening and diagnostic

A

SCREENING
Asymptomatic (At risk)
Large Group
Less Accurate
Not Conclusive
Less Expensive
Not Basis for Treatment
DIAGNOSTIC
Suggestive Clinical Picture
Single Subject
Accurate
Conclusive
Expensive
Basis for Treatment

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7
Q

large-scale screening of the whole population with no selection process.

A

Mass

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8
Q

selection of the high-risk population

A

High-Risk or Selective

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9
Q

the application of two or more screening tests in combination with one group of the population

A

multiphasic or multiple

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10
Q

difference between population approach and high risk strategy

A

POPULATION APPROACH

Not cost effective. Potential to alter the root cause of disease.
Large chance to reduce disease incidence. Small benefit to individual.
Poor subject motivation.

HIGH-RISK STRATEGY
Cost effective.
Fails to deal with the root cause of disease.
Small chance in reducing the disease incidence. Intervention appropriate to an individual.
Subject motivated

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11
Q

BENEFITS OF SCREENING TESTS

A

Improvedprognosisforsomecasesdetected.
* Less radical treatment (cures some early cases).
*Reassurance with negative test results.

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11
Q

LIMITATIONS OF SCREENING TESTS

A

*Hazard of screening(venipuncture, radiation)
*Resource costs(diversion of scarce resources to
screening program)
*False reassurance with false negative test results.
*Anxiety and depression with false positive results.

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12
Q

Newborn Screening, Cancer Screening, Sugar in Urine

A

Prescriptive Screening

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13
Q

examples of infancy screening test

A

Growth Charts Metabolic Screening Hearing Test

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14
Q

Screening for Immigrants, HIV Screening for Sex Workers, Blood Transfusion Screening

A

Prospective Screening:

15
Q

examples of pregnancy screening test

A

Weight
Complete Blood Count Blood Sugar

16
Q

examples of adults screening test

A

Lipid Profile Blood Pressure Body Mass Index

17
Q

examples of elderly screening test

A

Cancer Depression
Vitamin Deficiency

18
Q

CRITERIA FOR SUCCESSFUL SCREENING TEST

A

reliability, validity, acceptability

19
Q

Causes of Unreliability:

A

Observer variation
o Subject variation (biological)- sample
o Technical method error variation

20
Q

getting the same results when repeated in the same target individuals in the same settings.

A

Reliability

21
Q

should not be painful,unsafe, discomforting, embarrassing, or socially unaccepted.

A

Acceptability

22
Q

the test’s ability to distinguish between who has the disease and who does not.

A

Validity

23
Q

DISEASE CRITERIA

A

*Present in the population screened.
*High burden and of high public health concern.
*Screening and intervention must improve outcomes.
*Known natural history of the disease.

24
Q

TEST CRITERIA

A

Reliable,valid,simple,inexpensive,andverysafe. * Acceptable to subjects and providers.
* Cost-effective.
* Exit strategy

25
Q

Ability to truly identify those who have the disease. * True Positive -

A

sensitivity

26
Q

sensitivity formula

A

tp/ tp + fn

27
Q

specificity formula

A

tn/ tn + fp

28
Q

Ability to correctly identify those who do not have the disease.
* TrueNegative

A

specificity

29
Q

the proportion of individuals with a positive test (with the disease)

A

Positive Predictive Value

30
Q

the proportion of individuals with a negative test (without the disease)

A

Negative Predictive Value

31
Q

PPV formula

A

TP/ tp+ fp

32
Q

NPV formula

A

TN/ FN+TN

33
Q

Effects on Predictive Value:

A

Specificity Increases = PPV Increases
Sensitivity Increases = NPV Increases
Prevalence increases= PPV increases, NPV decreases and vice versa