Scientists ---REVERSE

Question 1

• Worked out structure of LDL receptor and studied familial hypercholesterolemia. Won Nobel prize for this

Answer 1

Mike Brown and Joe Goldstein

Question 2

• Discovered that the coat on coated vesicles in composed of clathrin. Clathrin consists of 3 copies of each of 2 proteins, arranged in a triskelion. Triskelions makeup the cages of clathrin-coated vesicles.

Answer 2

Barbara Pearse

Question 3

-Worked out the secretory pathway using pancreatic acinar cells. For this he received the Nobel Prize.

Answer 3

George Palade

Question 4

• Were instrumental in discovering dynamic instability, the way in which microtubules grow and depolymerize
• Also showed that xenopus extract mitotic cytosol induced the 5x turnover rate of the microtubule GTP cap (catastrophe) as occurs in interphase cytosol

Answer 4

Tim Mitchison and Mark Kirschner

Question 5

• Was the first to discover olfactory receptors, 1000s of G protein coupled receptors expressed in the nose olfactory bulb that detects different odors

Answer 5

Linda Buck

Question 6

• First, along with Mark Davis, to clone the T cell receptor subunits.

Answer 6

Steve Hedrick

Question 7

• Were the first to show that a viral oncogene, v-src, was really a normal cellular gene (c-src), that had been hijacked onto a virus and turned into an oncogene. (Additional mutations in the protein sequence were necessary to turn c-src into an oncogene). Received the Nobel prize for this.

Answer 7

Mike Bishop and Harold Varmus

Question 8

• Discovered that antibody diversity stems in large part from combinatorial rearrangement of the Variable regions of the heavy chain gene of immunoglobulins. Received the Nobel Prize for this discovery.

Answer 8

Susumu Tonegawa

Question 9

• Developed Gleevec, the first treatment to block a cancer-causing kinase and kill cancer cells in chronic myeloid leukemia (CML). His type of treatment is referred to as a “magic bullet”.

Answer 9

Brian Druker

Question 10

• Won the 2009 Nobel Prize in Medicine for elucidating the structure and function of telomere sequences and discovering the enzyme that copies them, telomerase.

Answer 10

Liz Blackburn and Carol Grieder

Question 11

• Showed that the kinase ATR monitors DNA replication forks and sends a signal that blocks activation of the mitotic kinase (CDK1/cylcin) until all DNA replication is complete

Answer 11

Zhongshen You

Question 12

• Worked out how mice detect kairomones from rat, cat and snake, and discovered that the kairomones are proteins of the Mup family

Answer 12

Lisa Stowers