Important stuff to know

Question 1

Tight junction

Answer 1

• Make cell sheets impermeable

- divide plasma membrane into two functionally different domains

Question 2

Adhesion belts

Answer 2

• Links actin cytoskeletons

- Provides structure to cell sheet

Question 3

Desmosomes

Answer 3

• link intermediary filament cytoskeleton

- provide strength to cell sheet

Question 4

Gap Junctions

Answer 4

• Allow for Coupling between cells
• electrical coupling: heart, brain, muscle cells
• Chemical coupling: fish pigment cells (cAMP), pancreas cells secreting in coordinate manner

Question 5

What are the functions of the ECM?

Answer 5

• Space for diffusion of O2 and nutrients
• Space for diffusion of growth factors
• Space for cells to migrate through
• Increase tissue strength, flexibility, and resistance to compression
• Template for cell regeneration
• Marker for tissue location

Question 6

What are the main types of proteins in the ECM?

Answer 6

• Big three: Collagen, elastin, GAGs & Proteoglycan

- Also fibronectin (FN)

Question 7

What do CDK1/Cyclin phosphorylate, and what does that cause to occur

Answer 7

• Pore proteins –> pores disassemble
• Lamins –> Lamina disassembles
• Histone H1 –> Chromosomes condense
• Transcription factors –> shuts off transcription
• Servant kinase
  
  • Activates a kinase that causes the nuclear envelope fo break down
  • Activates a kinase that causes microtubule GTPase to be modified so catastrophe happens more quickly