Science- Part 2 Flashcards
how does the skin make vitamin d
by absorbing ultraviolet radiation from the sun
what is the purpose of vitamin d
to help the large intestine aborb dietary calcium
what are melanocytes
cells in the epidermis that produce and distribute melanin, which is a skin pigment that helps protect against ultraviolet radiation
what are hormones
chemical messengers secreted by ductless glands to the cells and organs on which they have an effect (target sites)
which is faster hormones or nerves?
nerves. Hormones travel through blood, so they take much longer to get there than nerve signals.
Which lasts longer- hormones or nerves?
hormones. they can remain in the blood stream much longer than a nerve signal
what releases epinephrine (aka adrenaline)
the adrenal glands
hence why an adrenaline rush (hormone) lasts longer than initial fright (nerve signal)
what is an endocrine gland?
a gland that does not have a duct
what is an exocrine gland?
a gland that delivers its secretions by tube to an epithelial surace or mucosa
IT DOES HAVE A DUCT.
examples of exocrine glands/secretions
salivary glands- saliva
pancreatic amylase
why is the pancrease unique
it secrets both enzymes and hormones
give an example of the pancrease in the endocrine system
it releases insulin, which is a hormone that triggers uptake of glucose into cells. Lowers blood glucose levels.
what organs are in the endocrine system (8)
pineal gland pituitary gland thyroid gland hypothalamus thymus adrenal glands pancreas ovaries/testes
what do beta cells do
in the pancreas, they dectect the levels of glucose in the blood and adjust the amount of insuline they secrete
What cells are able to detect blood glucose levels?
alpha and beta cells in the pancreas
What do alpha cells do
In the pancrease, they dectect levels of glucose in the blood. If levels are too low, they can secrete glucagon.
What does glucagon do
stimulates its target cells in the liver to convert hepatic glycogen stores into glucose and relase that glucose into the blood
what mechanism is used for pancreatic cells to maintain blood sugar
negative feedback mechanisms
meaning you stop producing hormones when levels are reached
what disease results from pancreative hormone regulation malfunction
diabetes
how are MOST hormone levels regulated
through negative feedback
what is the integration center between the endcorine system and the nervous system? what does it do?
the hypothalamus
produces releasing hormones that stimulate &
inhibiting hormones that restrict hormones that come from the anterior pituitary gland
what secretes growth hormone
anterior pituitary
what happens when the anterior pituitary ignores GHIH
gigantism
long bones continue grow
what does thyroid hormone do
regulares growth, development an dmetabolic rate
what initiates the release of TH
TSH from the anterior pituitary
TSH is triggered by TRH from the hypothalamus
what causes hyperthyroidism
a malfunction of negative feedback loop of TSH
what is positive feedback in the endocrine system
increasing the amount of hormone in a situation
what hormone uses positive feedback during labor
ocytocin is produced by the hypothalamus and stored in the posterior pituitary
cervical stretching triggers the release of oxytocin
oxytocin stiumlates uterine contractions which causes more cervical stretching and more oxytocin
what is melatonin
a hormone produced by the pineal gland that maintain circadian rhythm
what are the target organs of melatonin
eye, hypothalamus and anterior pituitary
what secretes FSH
anterior pituitary
What does FSH do
stimulates the production of eggs in ovaries
stimulates production of estrogen from ovaries
stimulates production of sperm in testes
what is the ovaries’ primary hormonal secretion
estrogen
what secrets LH
anterior pituiary
What does LH do
trigger ovulation in ovaries
triggers testosterone production in testes
What is the primary homrone secreted by the testes? Where else can be it be secreted from?
Testosterone
adrenal glands in both men and women
What are estrogen and testosterone derived from?
choleserol because they are steroid hormones
What is a steroid hormone
a hormone made from cholesterol. lipid construction makes it easy for them to pass through membranes.
What is the main function of steroid hormones
to affect transcription (the expression of specific genes) in their target cells. Think seconary sex characeristics in pubery.
How do non-steriod hormones get into cells?
Via receptor sites on cell membranes
They bind to the receptors and that triggers internal signals within the cells
What is the thymus? What does it do?
A gland behind sternum in adults (much larger in children) that prouces immune nonsteriod hormones like Thymosin.
Also where T-cells of the immune system are produced
What is the parathyroid
A small group of four bean shaped encodrince glands underneath the thyroid gland. It secretes PTH when calcium levels are low.
What does PTH do?
regulates plasma calcium levels
indirectily activates osteoclasts from bones
It also inhibits the kidney’s ability to transfer calcium ions to urine
what are the steroid hormones
testosterone, estrogen
testosterone
testes
promotes development of male sex characteristics
estrogen
ovaries
promotes development of female sex characteristics
epinephrine
adrenal gland
regulates heart rate, blood rpessuer
FSH
anterior pituitary
stimulates development of eggs in ovareis and sperm in testes
Glucagon
pancreas
triggers liver to convert hepatic glycogen stores into glucose and release glucose into the blood
Growth Hormone
Anterior pituitary
stimualtes tissue growth
inhibiting hormones
hypothalamus
restrict the production of certain hormones
insulin
pancrease
a hormone that triggers the influx of glucose into cells, tthus loweing blood glucose levels
luteinizing hormoone
anterior pituitary
triggers ovulation in ovaries and production of testosterone by testes
melatonin
pineal gland
plaus a role in maintaining circadian ryhyms
oxytocin
posterior pituitary
stimulates uterine contractions during childbirth
parathyroid
parathyroid gland
elevates plasma calcium levels
releasing hormones
hypothalamus
stimulates the production of certain hormones
thyroid hormone
thyroid
regulates growth, development, metabolic rate
what is the function of the endocrine system
controlling the timing and number of hormones released
what directs the activity of the pituitary gland
the hypothalamus
what is the function of the urinary system
processing and exretion of fluids from the body
what is the primary organ of the urinary system
the kidney
what is the function of the kidney (3)
- filter metabolic waste from the blood
- regulate electrolyte and fluid balance in the blood
- influence on fluid balance by the kidneys affects blood volume in the cardiovascular system, resulting in changes in blood flow rate and blood pressure
what are the functional units of the kidneys
nephrons
What are the regions of the kidneys
renal corex (outer layer) renal medulla (inner layer)
describe the structure within the renal cortex
the entire kidney is made up of nephrons, which are little triangle portions
the top is the cortex, the inner part is the medulla
the cortex has arteries and veins coming in/out. They connect to the glomerular capsule. This is where they drop off wastes.
The filtrate runs through all the tubules (at one point dropping into the medulla) and then leaves either goes back into the blood through the interlobular vein or as urine through the renal papilla
what is a glomerulus
a network of capillaires where blood pushes water, sal, glucose, amino acids, and urea from the blood
think- waste drop off point
what is the stuff leaving the blood through the walls of the capillaries
filtrate
Where is filtrate collecteed?
The bowman’s capsule around the glomerulus
Where does filtrate go after bowman’s capsule
a crazy looking tube (proximal tubule) then into the medulla
what is the purpose of the proximal tubule
to reabsorb anyhhing the blood could still use like glucose
What happens after the proximal tubule reachss the medulla?
the remaining filtrate flows through th Loop of Henle, then through the distal tubule and back into the cortex trhough the collecting tubule
What is the purpose of the distal tubule
more reabsoprtion
what causes tubular reabsorption
osmotic pressure
when does filtrate become urine
when filtrate passes through the collecting ducts through the medulla
Where do collecting ducts dump urine
the renal pelvis of the kidney (the center of the kidney)
Where does urine go after the renal pelvis?
ureter then the bladder then urethra
how much liquid can th ebladder fold
400-800mL
what arteries/veins come to/from the kidney
renal artery brings blood in
renal vein takes blood out
what controls the diffusion of particular solutions to maintain water balance
the nephron of the kidneys
what three metabolic byproducts do the kidneys keep in check
urea, uric acid, and creatinine
what determines the water levels in our body
kidneys
pay attention to the osomotic pressure to see how much NaCL there is. Sodium causes Chloride to follow, affecting the osmotic pressure at the reabsorption parts.
how does dehydration affect kidneys
dehydration causes reduced blood volume, since blood is mostly water
this lowers blood pressure
how do the kidneys work with the heart
when blood pressure is out of normal range and it is not caused by hydration, the kidneys increase blood volume by allowing more absorption of filtrate
then, the renin-angiotensin-aldosterone system
what is renin
an enzyme released by the kidneys when reduced blood pressure is detected by baroreceptors in the aorta an cartoid arteries
renin creates angiotesnsin I from angiotennsiongen prouced in the liver
What converts Angiotensin I to angiotensin II
an enxyme produced by the liver and kidneys calle ACE
What is Angiotensin II
a secretion that acts to restore blood volume and blood presure by cocnstricting blood vessels, stimulating thirst, and stimulating production of aldosterone and antidiuretic hormone
what is aldosterone
a hormone secreted by the adrenal gland that increases reabsorption of sodium ions. This leads to an increase in reabsorption of cholide ions and water.
What is antidiuretic hormone
a hormone secreted by the pituitary gland that increases the amound of water able to be reabsorbed from the cleevting duct. The effects of aldosterone and and antidiuretic hormone are to increased blood volume while decreasing water lost from the body in urine.
Give the steps of the renin-angiotensin-aldosterone system
- The liver makes Angiotensinogen
- The kidneys make renin, which changes Angiotensinogen to Angiotensin I
- The liver and kidneys make ACE, which changes Angiotensin I to Angiotensin II
- Angiotensin II constricts blood vessels, stimulates thirst and triggers production of Aldosterone and Antidiuretic Hormone.
- Adrenal Gland secretes Aldosterone. This increases reabsorption of sodium ions. Pituitary gland secretes Antidiuretic hormone, which increases the amount of water able to be reabsorbed in collecting ducts.
what is the tube that delivers urine to the urinary bladder
ureter
where are the glomeruli and bowmans capsule located
in the renal cortex
what are antigens
things the body percieves as foreign
what are pathogens
things that are dangerous towards the body
what are allergies
the immune system’s response to forgein agents that are not pathogens
what is the first line of defense
innate immune system, a collection of non-specific barriers
what are external parts of the innate immune system
hair, skin, bacterial floramucus membranes, antimicrobial substances like mucus tears and saliva
what is the second line of defense
still the innate immune system, meaning theyre not specifc but these are internal where the first line is external
this include inflammation, production of interferon, and ingestiong of pathogens by phagocytes
what is a macrophage
- a large white blood cell that ingests foreign material - - puts the antigens on it’s cell membrane to alet patrolling T cells
- also send out ctyokines to alert other cells of danger
what is the name of a macrophage with antigens on its cell membrane
antigen-presenting cells