Science of Drug Misuse Flashcards
1
Q
What is dispositional tolerance?
A
Less drug reaches the active site
2
Q
What happens in dispositional tolerance?
A
Less drug absorbed
Drug metabolised faster
More drug excreted
3
Q
What is pharmacodynamic tolerance?
A
Site of action is less affected by the drug
4
Q
What happens in pharmacodynamic tolerance?
A
Fewer drug receptors
Less efficient drug receptors
5
Q
Physiology of the reward center?
A
Neurones project from the ventral tegmental area to the nucleus accumbens and prefrontal cortex.
When VTA neurones are stimulated dopamine is released, causing a sensation of pleasure/rewards.
6
Q
Actual purpose of the reward center?
A
Normally activated by eating, drinking and sex therefore encouraging healthy behaviours that lead to propagation of genes.
