schizophrenia (wk 9) Flashcards

1
Q

describe the prevalence of schizophrenia in the general population / between men and women.

at what age is it most frequently diagnosed? describe the gender difference for the age of onset

A

-~1% of population worldwide
-men/women seem to be at equal risk

-most freq diagnosed between age 15-45
-small gender diff for age of onset: men display symptoms earlier (early-mid 20s); women display later (late 20s-early 30s)

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2
Q

describe the course of schizophrenia (prodromal phase, onset of symptoms indicator, predicting course + outcome, what causes poorer outcomes)

A

-prodromal phase: variety of clinically significant symptoms may emerge slowly over time
-social isolation + withdrawal, poor hygiene, impairment in school/work fnxing, lack of interest, suspiciousness etc

-typically, development of positive symptoms mark onset of first episode of schizophrenia

-course + outcome n indiv patients is v difficult to predict

-poorer outcomes assoc w male gender, younger age of onset, delayed treatment

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3
Q

what are complications of schizophrenia?

A

-lower educational attainment
-higher unemployment rates (finding + maintaining)
-more likely to dev depression + substance use disorders
-schizophrenia tends to be a chronic + relapsing cond that will req support throughout the lifetime

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4
Q

compare positive and negative symptoms

A

-positive symptoms: more “obvious” symptoms of psychosis; addition of abnormal behaviors
-Delusions
-Hallucinations
-disorganized speech and/or Thought Disorder
-grossly disorganized / catatonic behaviors

-negative symptoms: absence / loss of typical behaviors
-diminished emotional expression (“flat affect”)
-alogia (poverty of speech)
-avolition (total lack of motivation)

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5
Q

explain/describe hallucinations. what are the most common type?

A

misinterpretations of sensory perception that occur while a person is awake + conscious
-can be in the presence or absence of corresponding stimuli
-people hear, see, smell, and/or feel things that are either not really present, OR not as how other people experience them

-auditory hallucinations are the most common type of hallucination

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6
Q

what are delusions? what are 4 common types of delusions (and which of these are the most common)? give examples for each

A

-implausible, strongly held beliefs that persist despite evidence contradicting them ; usu clearly false + represent abnormality in person’s thinking

  1. persecutory (most common): paranoid belief of being pursued, targeted, ridiculed, someone trying to harm them
    → eg: strangers on the street are CIA tailing them; nurses/drs in the hospital
  2. referential: belief that common, meaningless occurrences have significant + personal meaning
    → eg: song on the radio is about them
  3. religious: involve biblical / religious stories
    → eg God/Satan is speaking to me / controlling my actions / monitoring them
    -religiousness vs delusion: depends on intensity / scope of which it appears in other areas of life - religiousness doesn’t impair fnxing + doesn’t impact other areas of lives
  4. delusions of grandeur: belief they possess special abilities / knowledge
    → eg ability to influence world events / the future
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7
Q

describe the 5 ‘Stages of Alternate Reality’ that can be used to explain how immersed someone is in positive symptoms

A
  1. Cell phone
  2. Tablet
    → occasionally, get distracted by unusual / suspicious thought (eg is that person laughing at me?); however able to move on + detach
  3. Computer
  4. TV
    → unusual ideas more prevalent in daily life, eg that family is out to harm you – might spend a few hours a day engaging in that belief + feeling more fearful
    -harder to disengage from fears ATP
  5. IMAX
    → fully immersed in unusual belief/psychotic experience; like being in a “surround sound. 3D movie”
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8
Q

describe loosening of associations

A

-one feature of disorganized speech - lack of logical connections between ideas in speech
-ideas not related in an organized / coherent way
-No single coherent train of thought
-freq derailment [from idea to idea]
-Abnormal spread / unusual linking of words / wd meanings / ideas

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9
Q

what are some motor symptoms?

A

-can range from agitated movements (eg tics, repetitive movements) to immobility

-catatonic behavior: holding rigid, unusual postures + resisting efforts by others to change these postures
-waxy flexibility: will allow others to move their bodies into new positions + maintains these positions

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10
Q

what are the 2 ‘core’ negative symptoms?

A

-diminished emotional expression (“flat affect”): failure to convey emotion in face, tone of voice, body language etc

-avolition: decreased motivation + more limited ability to initiate / persist in self-directed activities
-can result in difficulties w grooming + basic hygiene

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11
Q

describe anhedonia and alogia (negative symptoms)

A

-anhedonia: ↓ ability to experience + recall pleasure / experiences assoc w reward

-alogia: lessening of speech, 2 forms:
-poverty of speech: amount of speech is greatly ↓
-poverty of content of speech: amount is adequate but speech communicates little information (vague + repetitive)

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12
Q

is cognitive impairment a diagnostic requirement? give examples of cognitive deficits commonly found in those with schizophrenia

A

-not part of the DSM5 criteria, but is often clinically relevant (+debate to add it to next DSM)

-wide-spread cognitive deficits (IQ, language, executive functioning, attention/processing speed, memory)

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13
Q

what are the diagnostic criteria of schizophrenia?

A

A. 2+ of the following, for a significant period of time during a 1mo period; AL one of these should incl 1-3 (positive symptoms)
1. delusions*
2. hallucinations*
3. Disorganized speech*
4. Grossly disorganized/catatonic behavior
5. Negative symptoms (ie diminished emotional expression, avolition)

B. for a significant period of time since onset, lvl of fnxing (eg work, self care, social relationships) is markedly below what was achieved before the onset
C. continuous signs of the disturbance persist for AL 6 months (must incl AL 1 month of symptoms from criteria A)

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14
Q

explain the Hearing Voices Movement and its contribution to CBT for Pyschosis

A

-peer support groups
-aim is for people to dev personal meaning abt their unusual experiences, normalize the experience of psychosis, share coping strategies

-many concepts from CBT for psychosis derived from early Hearing Voices groups in England

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15
Q

give an example of how social + cultural factors may impact individuals’ interpretations of their experiences with schizophrenia

A

-US patients experienced voices as violent/hateful + viewed them as a brain disease
-patients from Africa + India reported more positive experiences w voices, tended to view them as spirit guides, were not highly distress

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16
Q

what are some changes to the DSM5 regarding subtypes of schizophrenia and why?

A

-DSM4 recognized subtypes of schizophrenia (paranoid, catatonic, disorganized); DSM-5 does NOT recognize these distinctions
-symptom-based subtypes had little validity + reliability

17
Q

what is attenuated psychosis syndrome?

A

-listed under category of “Other Specified Schizophrenia Spectrum + Other Psychotic Disorders”
-resembles schizophrenia but doesn’t meet full criteria
-must have one of: delusions, hallucinations, or disorganized speech
-symptoms present AL 1/wk for the past month
-symptoms less severe, more transient, insight is maintained

18
Q

explain genetic causes of schizophrenia

A

-small genetic contribution, but unclear what the pattern of inheritance is
-child of parent w schizophrenia only has 13% chance; 2 parents has 40% chance
-twin of someone w schizophrenia only has 48% chance
→ likely not only one gene; more evidence there’s several genes which puts someone at greater risk
-individual “risk” genes have small effects
-epigenetics may be involved

19
Q

what is the dopamine hypothesis? what are the 3 primary pieces of evidence that support it?

A

-idea that people that positive symptoms were related to excess of dopamine in the brain; was prevalent for a long time

  1. post-mortem brain tissue found ↑ number of dopamine receptors (indicating more dopamine transmission)
  2. treat schizophrenia w antipsychotics, which blocks postsynaptic dopamine receptors
  3. amphetamines/cocaine that ↑ dopamine transmission can cause psychosis-like symptoms + paranoid ideation
20
Q

what are 3 pieces of evidence against dopamine hypothesis?

A
  1. discovered post-mortem brain tissue examined before was from patients who were on antipsychotics – since dopamine was being blocked, brain ↑ dopamine receptors
  2. dopamine byproducts aren’t universally ↑ in schizophrenia – when dopamine is broken down, see an ↑ in metabolites across the brain, but that was not seen
  3. discrepancy between drug action of antipsychotics + changes in symptoms: antipsychotics blocks dopamine receptors immediately, however don’t see change in person’s self-reported positive symptoms until several weeks
21
Q

what is the current thinking on how dopamine is related to schizophrenia?

A

-excess dopamine transmission in the striatum (part of midbrain involved in learning, [ ], motivation; associated w reduced PFC activity + cog deficits)

22
Q

what are some structural and functional brain differences of those with schizophrenia?

A

-eg larger ventricles (fluid-filled spaces in brain, suggesting loss of brain tissue)
-thinner cerebral cortex (outer layer which contributes to whole value; high density of neurons/connective tissues; supports fnxs like sensation, perception, motor processes)
-↓ PFC volume + in tasks, ↓ blood flow to PFC (area of brain might be working less efficiently)
-↓ temporal lobe volume (assoc w sensation, perception, memory)

23
Q

what are congenital + developmental risk factors of schizophrenia?

A

-developmental stressors may make a person more vulnerable: eg maternal viral exposure (the flu, rubella, measles); birth complications (eg low weight birth, prolonged labor, preterm delivery, fetal distress)

24
Q

what are environmental risk factors of schizophrenia?

A

-environmental factor: trauma in childhood linked to 3x greater chance of dev’g psychotic disorder (severe bullying, phys/sexual/emotional abuse, neglect)

25
Q

explain expressed emotion as a risk factor for relapse of schizophrenia

A

-expressed emotion includes:
-hostility
-critical attitudes/comments abt family member
-over-involvement: implanting into their affairs, overconcern for person
→ families w these 3 dimensions tend to be ↓ in general warmth + positive comments; research has shown

-family experiences + parenting styles do NOT cause schizophrenia

26
Q

what is the diathesis-stress model of schizophrenia?

A

-a predisposing vulnerability/diathesis: eg genetic differences, subtle brain injuries during fetal devt/birth complications, diffs in neurotransmitter transmission

-stress: eg emerging demands of adolescence/maturation, ↑ educational demands, navigating social life, ↑ demands from work/families, exploring identity/sexuality / new social relationships

-thought that emerging demands overwhelms already weakened systems

27
Q

how does cannabis use affect the risk of psychotic illness?

A

-emerging research seems to be some risk for young adults
-can ↑ risk of dev’g primary psychotic illness in those already vulnerable
-using <25yrs may dev schizophrenia at younger age than they would’ve
-using cannabis may disrupt typical pathways of development in the brain

28
Q

what are the medication options for schizophrenia? side effects? strengths/weaknesses?

A
  1. first generation / typical antipsychotics (dev’d ~50s): eg Chlorpromazine (Thorazine), Haloperidol (Haldol)
    -↓ dopamine transmission / positive symptoms
    -however, adverse side effects: dry mouth, muscle stiffness, weight gain, sexual dysfunction, tardive dyskinesia
    -tardive dyskinesia: movement disorder characterized by repetitive, involuntary body movements
  2. second generation/atypical antipsychotics: more transient (not a full) blockage of dopamine receptors, allowing more normal dopamine transmission
    -also affects other neurotransmitter systems (eg serotonin)
    -Risperidone, Olanzapine, Seroquel, Abilify
    -assoc w fewer side effects, however still high rates of non-adherence
    -meds improve positive symptoms (for ~2/3 of patients) + some negative symptoms
    -BUT do little for cog impairment + social fnxing
29
Q

what are features of CBT for pyschosis?

A

-psycho-education abt schizophrenia + normalization of symptoms / unusual experiences
-discuss client’s hallucinations + delusional beliefs in detail + their interpretations of them
-collaboratively dev an understanding of what psychosis is + what may have contributed to its development

30
Q

how are thought records used in CBT for psychosis?

A

-thought records to monitor positive symptoms (eg freq of voices, conviction of belief, where/when) + coping attempts
-thought challenging + behavioral experiments to test out beliefs
→ question interpretations of events + dev alt explanations
-ID maladaptive coping strategies + build more adaptive coping strategies

31
Q

what are strengths of CBT for psychosis?

A

→ National Institute for Clinical Excellence in UK recommends CBT for psychosis as a standard of care
-small-moderate effect sizes for improving positive / negative symptoms
-moderate effect sizes for patients w med-resistant psychosis

32
Q

describe family therapy for schizophrenia

A

-psychoeducation abt schizophrenia
-strategies to provide support for the family member
-try to ↓ emotional expression + other stressors in the home
-help family members to dev their own coping skills + connect w supportive resources

33
Q

describe social skills training for schizophrenia

A

-practice social skills: appropriate social intxn, social conversational skills, appropriate disclosure (how do you decide who to tell you have schizophrenia? What does this conversation sound like?) etc

-job-related skills: job training; interview skills; creating a resume etc
-household tasks, hygiene etc
→ promotes independence + ↓ stress

34
Q

describe cognitive remediation for schizophrenia

A

-[ ] on improving cog abilities eg memory, attn, executive fnxing
-teaching compensatory strategies (eg how to make up for a poor memory)
-practice exercises
-effects for enhancing cognition + community fnxning (eg employment)