SCHIZOPHRENIA P3 Studies

Question 1

two biological explanations for schizophrenia

Answer 1

genetic basis and neural correlates

Question 2

genetic explanations for schizophrenia

Answer 2

family studies, candidate genes, mutation

Question 3

neural explanations for schizophrenia

Answer 3

dopamine hypotheses

Question 4

family studies exp for sz

Answer 4

Gottesman 1991 - 2%aunt, 9% sibling, 48% identical twin
found risk increases with genetic similairty
supports importance of genes in schziophrenia

Question 5

candidate genes exp for sz

Answer 5

early belief was role of a single faulty gene causing SZ.
Ripke et al 2014 human genome project analysis - in 37,000 with sz vs 113,000 without, 108 genetic combinations were associated with increased risk
-range of different candidate genes suggests schizophrenia is aetiologically heterogenous