Schizophrenia Jeopardy Flashcards
Negative Symptoms
M>F Alogia Affective fattening Evolution Anhedonia (sx of MDD)
Positive Symptoms
delusions
disorganized thinking
hallucinations
1 of this to meet DSM5 A criteria of Schizophrenia
schizophreniform disorder
sx bw 1 - 6 months of criteria A schizophrenia
Rule out diagnosis
before schizophrenia
Other psychotic disorder Childhood developmental disorders Medical or neuro illness Substance/medication abuse Personality disorders Mood disorders
Cognitive Symptoms
SMART
Speed Memory Attention Reasoning Tact (social)
Catatonia
stupor waxy flexibility mutism negativism stereotypy echolalia
Hypnopompic hallucination
heard when waking up
Negative or Cognitive sx
Early in dx
Worsen during active periods
Do not respond to anti-psychotic
only __ pts with schizophrenia get married
30-40%
limited social contact
schizophrenia with 1 single episode
10%
intermittent course 30%
chronic course 60%
Prodrome
seen in 85% prior to 1st psychotic episode
negative prognostic sign
months-years
beginning of functional decline
different average age of onset bw M and F
2nd smaller peak age of onset peak for females after age 40
peak age of onset is same
Dec life expectancy bc
cardiovascular disease
% of pts with schizophrenia that live independently
33%
course of dz in Males more severe than Females
bc MALES develop illness earlier
continous tx goal
prevent relapse into the active phase
“lowest effective dose” can cause
INC risk of relapse
but used bc greater sensitivity to medication AE during first episode
common reason pt with schizophrenia are psychiatric hospitalized
psychosis/active phase of illness
response time of anti-psychotic rx
2 weeks
except for clozapine
if no good effect seen, less likely it will work by 4 weeks
Clozapine
Lithium
DEC risk of suicide
Clozapine
persistence of + sx
failure of >2 antipsychotic trial
co-morbid substance abuse
recurrent suicidality/violence
AE: sialorrhea weight gain sedation myocarditis lower seizure threshold
FGAs goal %
> 60% in mesolimbic tract
but 80% AE
Low potency anti-psychotic AE
anti-cholinergic sx dry mouth constipation BV urinary hesitance
Dystonia
EPS side effect
INC risk in young males
