Schizophrenia and Parkinson's Disease Drug Therapy

Question 1

psychosis

Answer 1

breakdown of personality, thought patterns unrelated to real life, lose touch with reality

Question 2

schizophrenia

Answer 2

increase in DA and 5HT, excessive activity of NTs, possible cause from genetic abnormal neural development

Question 3

schizophrenia

Answer 3

increase in DA and 5HT, excessive activity of NTs, possible cause from genetic abnormal neural development

Question 4

symptoms of schizophrenia

Answer 4

delusions, hallucinations, disorganized speech and behavior, socially withdrawn, poverty of speech, diminished emotional expression, decreased motivation

Question 5

drug class for tx of schizophrenia

Answer 5

antipsychotics

Question 6

types of antipsychotics

Answer 6

typical antipsychotics

antitypical antipsychotics

Question 7

MOA of typical antipsychotics

Answer 7

block DA receptor, preventing it from binding

Question 8

SE of typical antipsychotics

Answer 8

anticholinergic effects, sedation, neurological symptoms: EPS, dystonic reactions, akathisia, tardive dyskinesia, parkinsonism

Question 9

tx for side effects of typical antipsychotics

Answer 9

anticholinergics

block ACH

Question 10

MOA of atypical antipsychotics

Answer 10

work on DA and 5HT receptors in brain

Question 11

pt teaching/ side effects of atypical antipsychotics

Answer 11

weight gain, hyperlipidemia, dizziness, headache, hypotension, low risk for EPS, dry mouth, blurred vision, drowsiness

Question 12

Parkinson’s disease

Answer 12

progressive disorder caused by accelerated aging and destruction of neurons in basal ganglia in brain that produce DA

Question 13

symptoms of Parkinson’s disease

Answer 13

resting tremors, muscle rigidity, posture balance disturbances, sweating, salivation, bradykinesia
no cure

Question 14

NT involved in Parkinson’s disease

Answer 14

decrease in DA in basal ganglia, increase in ACH

Question 15

goal of antiparkinson drugs

Answer 15

increase DA levels, decrease ACH levels

DA cannot cross BBB synthetically, usually requires poly pharmacy

Question 16

drug class for treatment of Parkinson’s

Answer 16

dopaminergics

Question 17

drug classes for treatment of Parkinson’s

Answer 17

dopaminergics
antihistamines
anti-viral
DA conserver/MAO-B inhibitor

Question 18

pt teaching/SE of dopaminergics

Answer 18

N/V, loss of appetite, hypotension, dizziness, sleeplessness, off-on phenomenon

Question 19

MOA of antihistamines

Answer 19

anticholinergic effects (block ACH)

Question 20

pt teaching/SE of anticholinergics

Answer 20

dry mouth, constipation, urinary retention, increased HR, mydriasis

Question 21

MOA of anti-virals

Answer 21

increased activity of DA in basal ganglia, decreases reuptake back into nerve endings

Question 22

pt teaching/SE of anti-viral drugs

Answer 22

dry mouth, GI disturbances, dizziness, confusion, skin discoloration

Question 23

MOA of DA conserver/MAO-B inhibitor

Answer 23

inhibits metabolism of DA in brain

Question 24

pt teaching/SE of

Answer 24

mouth ulcers, sweating, HA, GI upset, sleep disturbances, monitor for arryhtmias