Schizophrenia Flashcards
What is the first antipsychotic called
Chlorpromazine
What was the first antipsychotic actually developed for
Anti histamine
What does the first antipsychotic do
It attentuates positive symptoms without excessive sedation
Not depressant - preserves intellectual function
Classical/ typical/ first generation neuroleptic. Had a profound impact on treatments allowed people to be released from institutions - symptom control
Chemical classses of typical neuroleptics
Phenothiazine
Butyrophenones
Thioxanthines
What makes these drugs dirty drugs
The act on many receptors
What receptors do these drugs act
Dopamine D1 and D2 receptor families Ach muscarinic Histamine H1 Noradrenaline alpha adrenoreceptor 5HT serotonin
What does interacting with many receptor cause
Lots of SE
What receptor out of the ones the drugs act on has been implicated as the causation from this efficacy of the drug to the receptors
Dopamine receptors - dopamine hypothesis
When are atypical neuroleptic used
As a second generation when the typical don’t work
When were they developed
More recent than typical
What makes them atypical drugs
Block dopamine
If they treat negative symptoms they are atypical
Distinction from typical on the basis of
Pharmacological profile - higher dopamine selectivity
Fewer pyramidal side effects - motor
More effective against the negative symptoms
More effective in the treatment resistant group
Sulpiride, amisulpride- selective dopamine antagonists D2/D3 receptors
Clozapine facts
Best example of an atypical neuroleptic More effective antipsychotic But it is a dirty dirty drug binding to many receptors Fewer motor SE And can control the negative symptoms
Risperidone, zotepine, sertindole
Serotonin, dopamine antagonists
Quetiapine
Novel type - first line for newly diagnosed