Schizophrenia Flashcards

1
Q

Onset is typically ____ in men compared to women

A

earlier (late teens/early 20s)

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2
Q

___show a bimodal distribution of onset of schizophrenia with a peak in the late 20s and another peak in middle age

A

women

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3
Q

Monozygotic twins have a ____ rate of concordant schizophrenia

A

50%

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4
Q

Newborns with fathers > _____ years old have an increased risk of schizo

A

60

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5
Q

There is evidence for too little dopamine in the ____ tract and too much in the _____ tract

A

mesocortical

mesolimbic

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6
Q

Heavy ____ use in adolescence is associated with increased risk

A

marijuana

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7
Q

Pathological findings include _____ ventricles and _____ cortical volume

A

enlarged

decreased

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8
Q

Decreased cortical volume appears to be due to: ______ (neuronal loss/reduced density of axons, dendrites, synaptic connections)

A

reduced density of axons, dendrites, synapses

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9
Q

Impaired _____ eye movements and _____ saccades are also seen

A

smooth pursuit

disinhibited

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10
Q

To be classified as schizophrenia, symptoms must be present for at least ____ months

A

6

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11
Q

Hallucinations are typically ____

A

auditory

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12
Q

The classic presentation of hallucinations in schizos:

A

multiple voices speaking to each other, commenting on patient’s thoughts and surroundings

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13
Q

____ are fixed false beliefs

A

delusions

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14
Q

Capgras syndrome:

A

delusion that a familiar person has been replaced by an imposter

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15
Q

Fregoli’s phenomenon:

A

delusion that persecutors or familiar people can assume the guise of strangers

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16
Q

In _____, speech wanders but eventually returns to the original point

A

circumstantiality

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17
Q

In ____, speech wanders and does not come back

A

tangentiality

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18
Q

Presentations of catatonia

A
mutism
extreme psychomotor retardation
repetitive purposeless movement
waxy flexibility
posturing/rigidity
agitation
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19
Q

A catotonic symptom associated with a medial emergency is _____

A

refusal to eat or drink

20
Q

Abulia

A

indifference, lack of impulses to act or think

21
Q

alogia

A

poverty of speech

22
Q

avolition

A

lack of motivation

23
Q

anhedonia

A

lack of enjoyment

24
Q

acathexis

A

lack of appropriate emotional responses

25
_____ symptoms are the best predictor of function in schizos
cognitive
26
____ skills are often relatively spared as compared to other areas of cognition, leading to ____ of cognitive function
verbal/vocab | overestimation
27
There is typically _____ arm swinging while walking in schizos
decreaed
28
The ____ stage is key for early detection and treatment of schizo, leading to better outcomes if caught.
prodromal
29
The longer symptoms are untreated or inadequately treated, the ____ the time to remission, ____ residual symptoms, and ____ long term prognosis
longer more worse
30
downward drift hypothesis:
individuals with schizo enter into a lower socioeconomic group as a direct result of the illness
31
One prominent finding in schizos is _____, or lack of insight
anosognosia
32
Anosognosia is due to an abnormality within the brain's ____ and ____ lobes
frontal, parietal
33
Schizo treatments typically help with ____ symptoms, but generally don't improve ____ symptoms as much
positive | negative
34
_____ is the most common first gen anti-psychotic used
haldol (haloperidol)
35
Extrapyramidal side effects of 1st gen anti-psychotic meds include
dystonia, akathisia, bradykinesia, and tardive dyskinesia
36
akathisia
restlessness
37
_____ ____ ____ syndrome is a side effect of 1st gen anti-psychotics and is characterized by rigidity, myoglobinuria, autonomic instability, and hyperpyrexia
neuroleptic malignant syndrome
38
medical emergency as a result of some 1st gen anti-pyschotics
neuroleptic malignant syndrome
39
tardive dyskinesia
stereotypic oral/facial movements as a result of long term anti-psychotic use
40
_____ is the most effective 2nd gen anti-psychotic, but there are some bad side effects associated with it
clozapine
41
Side effects of clozapine
neutorpenia/agranulocytosis; seizure
42
weight gain may be seen with use of _____ or ______
olanzapine, clozapine
43
____ carries a risk of hyperprolactinemia
risperidone
44
2nd gen anti-psychos may prolong the _____ interval
QT
45
Psychotherapy has been shown to be most helpful as regards to _____ therapy
family
46
belief that people with severe mental illness decompensate in response to stressors and can function better if stressors are proactively addressed
assertive community treatment