Schizophrenia

Question 1

Cornblatt + Obushowski, 1997

Answer 1

Neurodevelopmental model: genetic, brain abnormalities, triggers + buffers, plus deficits in STM, WM, attention + eye-movements

Question 2

Strauss et al. 1991

Answer 2

Posner paradigm - no difference in anti-saccadic movement - also visual exploration and central paradox

Question 3

Lu et al. 2012

Answer 3

Takes a year to stabilise cognitive factors. Symptom profiles much quicker

Question 4

Gu et al. 2000

Answer 4

Reduced grey matter in frontal lobe

Question 5

Friston et al. 1992

Answer 5

Reduced blood flow in global pallidus

Question 6

Dopamine hypothesis

Answer 6

Hyperactive DA? Psychostimulant effects. Some evidence for dopamine in tissue. Do drugs reverse mechanism or induce suppression

Question 7

Neurodevelopmental model: genetic, brain abnormalities, triggers + buffers, plus deficits in STM, WM, attention + eye-movements

Answer 7

Cornblatt + Obushowski, 1997

Question 8

Posner paradigm - no difference in anti-saccadic movement - also visual exploration and central paradox

Answer 8

Strauss et al. 1991

Question 9

Takes a year to stabilise cognitive factors. Symptom profiles much quicker

Answer 9

Lu et al. 2012

Question 10

Reduced grey matter in frontal lobe

Answer 10

Gu et al. 2000

Question 11

Reduced blood flow in global pallidus

Answer 11

Friston et al. 1992