Schizophrenia

Question 1

Know the diagnostic criteria for schizophrenia

Answer 1

•Characteristic symptoms - 2 required for at least one month:
o Delusions
o Hallucinations
o Disorganized speech
o Grossly disorganized or catatonic behavior
o Negative symptoms such as affective flattening

• Social/occupational dysfunction in work, interpersonal relatioships, or self-care
• Duration of symptoms – for at least 6 months for full form
• Mood disorder has not played prominent part in illness
• Illness – not due to medication/medical condition/substance abuse
• Not part of autism or other pervasive developmental disorder.

Question 2

Know the proposed causes of schizophrenia: Environmental

Answer 2

x

Question 3

Know the proposed role of the major neurotransmitters and neural circuits involved

Answer 3

x

Question 4

Know the major classes of antipsychotic drugs, their side effects, and proposed mechanism of action

Answer 4

x

Question 5

What is the prevalence of Schizophrenia?

Answer 5

1% of people

Question 6

What is the typical age of onset for Schizophrenia?

Answer 6

15-35 years (aka late adolescence or early adulthood)

Question 7

Clinica symptoms of schizophrenia

Answer 7

Positive symptoms: Hallucinations and delusions

Negative symptoms: Loss of pleasure, loss of will or drive, disorganized or impoverished thoughts and speech, flattened affect

Cognitive impairment: Have an IQ on average about 5-10pts below the general population

Question 8

Know the proposed causes of schizophrenia: Genetic

Answer 8

x