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Neuro Section 4 > Drugs, Receptors > Flashcards

Drugs, Receptors Flashcards

1
Q

Drug class and mechanism of Cocaine

A

Stimulant
Acts on Dopamine transporter
(Also Serotonin transporter, and Norepinephrin transporter)

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2
Q

Drug class and mechanism of Methamphetamine

A

Stimulant
Acts on Dopamine transporter
(Also Serotonin transporter, and Norepinephrin transporter)

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3
Q

Drug class and mechanism of Nicotine

A

Stimulant

Acts on nicotinic receptor

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4
Q

Drug class and mechanism of MDMA (ecstasy)

A

Stimulant

Actos on Serotonin transporter > Dopamine stransporter, also on Norepinephrin transporter

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5
Q

Drug class and mechanism of Oxycodone/Hydrocodone

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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6
Q

Drug class and mechanism of Heroin

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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7
Q

Drug class and mechanism of Morphine

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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8
Q

Drug class and mechanism of Codeine

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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9
Q

Drug class and mechanism of Fentanyl

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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10
Q

Drug class and mechanism of Meperidine

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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11
Q

Drug class and mechanism of Methadone

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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12
Q

Drug class and mechanism of Alcohol

A

CNS Depressant

Increase GABA-A, decreases NMDA

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13
Q

Drug class and mechanism of Benzodiazepines

A

CNS Depressant

Increase GABA-A only

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14
Q

Drug class and mechanism of Barbiturates

A

CNS Depressant

Increase GABA-A, decreases NMDA

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15
Q

Drug class and mechanism of Marijuana

A

Cannabinoid

CB-1 receptor (Gi/o) agonist

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16
Q

Drug class and mechanism of Indoleamine (LSD)

A

Hallucinogen

5HT-2A receptor (Gq) partial agonist

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17
Q

Drug class and mechanism of Pheylethylamines (MDMA)

A

Hallucinogen

5HT-2A receptor (Gq) partial agonist

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18
Q

Drug class and mechanism of Phencyclidine

A

Dissociative Anesthetic

NMDA receptor antagonist

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19
Q

Drug class and mechanism of Ketamine

A

Dissociative Anesthetic

NMDA receptor antagonist

20
Q

Drug class and mechanism of Glues, Adhesives, Aerosol, Paints, etcs

A

Inhalants

General CNS depression, likely altering membrane permeability and neurotransmission

21
Q

Drug class and mechanism of Scopolamine

A

Anticholinergics

Block muscarinic cholinergic

22
Q

Drug class and mechanism of OTC antihistamines

A

Anticholinergics

Block muscarinic cholinergic

23
Q

Drug class and mechanism of Atropine

A

Anticholinergics

Block muscarinic cholinergic

24
Q

Drug class and mechanism of Chlorpromazine

A

First generation Antipsychotics
Blockade of D2 receptors (and 5HT2A receptors)
D2>5HT2A

(good against positive symptoms)

25
Q

Drug class and mechanism of Haloperidol

A

First generation Antipsychotics
Blockade of D2 receptors (and 5HT2A receptors)
D2>5HT2A

(good against positive symptoms)

26
Q

Drug class and mechanism of Aripiprazole

A

Second generation Antipsychotics
Blockage of D2 and 5HT2A receptors
5HT2A > D2

(good against negative symptoms)

27
Q

Drug class and mechanism of Clozapine

A

Second generation Antipsychotics
Blockage of D2 and 5HT2A receptors
5HT2A > D2

*Poor D2 block, yet great antipsychotic
(good against negative symptoms)

28
Q

Drug class and mechanism of Olanzapine

A

Second generation Antipsychotics
Blockage of D2 and 5HT2A receptors
5HT2A > D2

(good against negative symptoms)

29
Q

Drug class and mechanism of Quetiapine

A

Second generation Antipsychotics
Blockage of D2 and 5HT2A receptors
5HT2A > D2

(good against negative symptoms)

30
Q

Drug class and mechanism of Risperidon

A

Second generation Antipsychotics
Blockage of D2 and 5HT2A receptors
5HT2A > D2

(good against negative symptoms)

31
Q

Drug class and mechanism of Fluoxetine, Paroxetine, Sertraline, Citalopram

A

SSRIs

Block Serotonin transmitter, preventing reuptake of 5HT

32
Q

Drug class and mechanism of Venlafaxine, Desvenlafaxine, Duloxetine

A

Serotonin-Norepinephrin Reuptake Inhibitor

Blocks Norepinephrine and Serotonin transmitters, preventing reuptake of Norepi and 5HT

33
Q

Drug class and mechanism of Amitriptyline, Nortriptyline, Desipramine, Imipramine

A

Tricyclic Antidepressants

Blocks Norepinephrine and Serotonin transmitters, preventing reuptake of Norepi and 5HT

Second line

34
Q

Drug class and mechanism of Phenelzine, Selegeline, Tranylcypromine, Isocarboxazid

A

Monamien Oxidase Inhibitors

Inhibits MAO, which degrades dopamine

35
Q

Drug class and mechanism of Carbamazepine

A

Anti-Seizure

Inhibit VSSC (Na channel) in use-dependent manner to suppress repetitive APs

P450 metabolized

36
Q

Drug class and mechanism of Phenytoin

A

Anti-Seizure

Inhibit VSSC (Na channel) in use-dependent manner to suppress repetitive APs

Zero-orde kinetics, P450 metabolized

37
Q

Drug class and mechanism of Lamotrigine

A

Anti-Seizure

Mechanism unclear, used to suppressed repetitive APs

38
Q

Drug class and mechanism of Zonisamde

A

Anti-Seizure

Inhibit VSSC (Na channel) in use-dependent manner to suppress repetitive APs

P450 metabolized

39
Q

Drug class and mechanism of Lacosamide

A

Anti-Seizure

Inhibit Na channel via ENHANCEMENT OF SLOW INACTIVATION without blocking channel directly and prolonging fast activation

*CYP450 metabolized but doesn’t inhibit/induce = DDIs negligible)

40
Q

Drug class and mechanism of Ethosuximide

A

Anti-Seizure

Inhibit low-threshold T-type Ca channel

CYP3A4 metabolized

41
Q

Drug class and mechanism of Levetriacetam

A

Anti-Seizure

Mechanism unknown, disrupts SV2A synaptic vesicle protein, affects Ca channel

42
Q

Drug class and mechanism of Topiramate (Topamax)

A

Anti-Seizure

Inhibit VSSC (Na channel ) in a use dependent manner to suppress repetitive APs

May also increase GABA and decrease GLU activity

CYP450 metabolism

43
Q

Drug class and mechanism of Valproic Acid (Depakene) and Divaproex (Depakote)

A

Anti-Seizure

Unclear, but increases GABA function and limits T-type Ca channels

44
Q

Drug class and mechanism of Gabapentin

A

Anti-Seizure

GABA analog, but acts at Ca channels to decrease GLU

45
Q

Drug class and mechanism of Benzodiazepines

A

Anti-Seizure

Enhance GABA activity

46
Q

Drug class and mechanism of Phenobarbital

A

Anti-Seizure

Enhance GABA, decrease GLU

Classic CYP450 inducer

Neuro Section 4 (23 decks)

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