Drugs, Receptors Flashcards by Kelly Finnegan

Q

Drug class and mechanism of Cocaine

A

Stimulant
Acts on Dopamine transporter
(Also Serotonin transporter, and Norepinephrin transporter)

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Q

Drug class and mechanism of Methamphetamine

A

Stimulant
Acts on Dopamine transporter
(Also Serotonin transporter, and Norepinephrin transporter)

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Q

Drug class and mechanism of Nicotine

A

Stimulant

Acts on nicotinic receptor

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Q

Drug class and mechanism of MDMA (ecstasy)

A

Stimulant

Actos on Serotonin transporter > Dopamine stransporter, also on Norepinephrin transporter

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Q

Drug class and mechanism of Oxycodone/Hydrocodone

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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Q

Drug class and mechanism of Heroin

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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Q

Drug class and mechanism of Morphine

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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Q

Drug class and mechanism of Codeine

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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Q

Drug class and mechanism of Fentanyl

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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Q

Drug class and mechanism of Meperidine

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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Q

Drug class and mechanism of Methadone

A

Opiod

Agonist of Mu-opiod receptor (Gi/o)

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Q

Drug class and mechanism of Alcohol

A

CNS Depressant

Increase GABA-A, decreases NMDA

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Q

Drug class and mechanism of Benzodiazepines

A

CNS Depressant

Increase GABA-A only

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Q

Drug class and mechanism of Barbiturates

A

CNS Depressant

Increase GABA-A, decreases NMDA

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Q

Drug class and mechanism of Marijuana

A

Cannabinoid

CB-1 receptor (Gi/o) agonist

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Q

Drug class and mechanism of Indoleamine (LSD)

A

Hallucinogen

5HT-2A receptor (Gq) partial agonist

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Q

Drug class and mechanism of Pheylethylamines (MDMA)

A

Hallucinogen

5HT-2A receptor (Gq) partial agonist

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Q

Drug class and mechanism of Phencyclidine

A

Dissociative Anesthetic

NMDA receptor antagonist

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Q

Drug class and mechanism of Ketamine

A

Dissociative Anesthetic

NMDA receptor antagonist

Q

Drug class and mechanism of Glues, Adhesives, Aerosol, Paints, etcs

A

Inhalants

General CNS depression, likely altering membrane permeability and neurotransmission

Q

Drug class and mechanism of Scopolamine

A

Anticholinergics

Block muscarinic cholinergic

Q

Drug class and mechanism of OTC antihistamines

A

Anticholinergics

Block muscarinic cholinergic

Q

Drug class and mechanism of Atropine

A

Anticholinergics

Block muscarinic cholinergic

Q

Drug class and mechanism of Chlorpromazine

A

First generation Antipsychotics
Blockade of D2 receptors (and 5HT2A receptors)
D2>5HT2A

(good against positive symptoms)

Drug class and mechanism of Haloperidol

First generation Antipsychotics Blockade of D2 receptors (and 5HT2A receptors) D2>5HT2A (good against positive symptoms)

Drug class and mechanism of Aripiprazole

Second generation Antipsychotics Blockage of D2 and 5HT2A receptors 5HT2A > D2 (good against negative symptoms)

Drug class and mechanism of Clozapine

Second generation Antipsychotics Blockage of D2 and 5HT2A receptors 5HT2A > D2 *Poor D2 block, yet great antipsychotic (good against negative symptoms)

Drug class and mechanism of Olanzapine

Second generation Antipsychotics Blockage of D2 and 5HT2A receptors 5HT2A > D2 (good against negative symptoms)

Drug class and mechanism of Quetiapine

Second generation Antipsychotics Blockage of D2 and 5HT2A receptors 5HT2A > D2 (good against negative symptoms)

Drug class and mechanism of Risperidon

Second generation Antipsychotics Blockage of D2 and 5HT2A receptors 5HT2A > D2 (good against negative symptoms)

Drug class and mechanism of Fluoxetine, Paroxetine, Sertraline, Citalopram

SSRIs Block Serotonin transmitter, preventing reuptake of 5HT

Drug class and mechanism of Venlafaxine, Desvenlafaxine, Duloxetine

Serotonin-Norepinephrin Reuptake Inhibitor Blocks Norepinephrine and Serotonin transmitters, preventing reuptake of Norepi and 5HT

Drug class and mechanism of Amitriptyline, Nortriptyline, Desipramine, Imipramine

Tricyclic Antidepressants Blocks Norepinephrine and Serotonin transmitters, preventing reuptake of Norepi and 5HT *Second line*

Drug class and mechanism of Phenelzine, Selegeline, Tranylcypromine, Isocarboxazid

Monamien Oxidase Inhibitors Inhibits MAO, which degrades dopamine

Drug class and mechanism of Carbamazepine

Anti-Seizure Inhibit VSSC (Na channel) in use-dependent manner to suppress repetitive APs *P450 metabolized*

Drug class and mechanism of Phenytoin

Anti-Seizure Inhibit VSSC (Na channel) in use-dependent manner to suppress repetitive APs *Zero-orde kinetics, P450 metabolized*

Drug class and mechanism of Lamotrigine

Anti-Seizure Mechanism unclear, used to suppressed repetitive APs

Drug class and mechanism of Zonisamde

Anti-Seizure Inhibit VSSC (Na channel) in use-dependent manner to suppress repetitive APs *P450 metabolized*

Drug class and mechanism of Lacosamide

Anti-Seizure Inhibit Na channel via ENHANCEMENT OF SLOW INACTIVATION without blocking channel directly and prolonging fast activation *CYP450 metabolized but doesn't inhibit/induce = DDIs negligible)

Drug class and mechanism of Ethosuximide

Anti-Seizure Inhibit low-threshold T-type Ca channel *CYP3A4 metabolized*

Drug class and mechanism of Levetriacetam

Anti-Seizure Mechanism unknown, disrupts SV2A synaptic vesicle protein, affects Ca channel

Drug class and mechanism of Topiramate (Topamax)

Anti-Seizure Inhibit VSSC (Na channel ) in a use dependent manner to suppress repetitive APs May also increase GABA and decrease GLU activity *CYP450 metabolism*

Drug class and mechanism of Valproic Acid (Depakene) and Divaproex (Depakote)

Anti-Seizure Unclear, but increases GABA function and limits T-type Ca channels

Drug class and mechanism of Gabapentin

Anti-Seizure GABA analog, but acts at Ca channels to decrease GLU

Drug class and mechanism of Benzodiazepines

Anti-Seizure Enhance GABA activity

Drug class and mechanism of Phenobarbital

Anti-Seizure Enhance GABA, decrease GLU *Classic CYP450 inducer*