Schizophrenia 2

Question 1

What do agonistic drugs do for schizophrenia?

Answer 1

MIMICS - increases synthesis of neurotransmitter molecules

Question 2

What do antagonistic drugs do for schizophrenia?

Answer 2

BLOCKS - the synthesis of neurotransmitter molecules

Question 3

What system is schizophrenia a disorder of?

Answer 3

The dopaminergic system.

Question 4

Name the two tracts in the dopaminergic system that have a role in schizophrenia?

Answer 4

Mesolimbic and nigrostriatal

Question 5

What are the main molecules with abnormalities involved in schizophrenia?

Answer 5

Dopamine.

Question 6

Name some of the D2 family of treatments for schizophrenia.

Answer 6

Haloperidol, spiroperidol, chlorpromazine.

Question 7

What does an antagonistic treatment do for receptor activity?

Answer 7

Stops receptor activity.

Question 8

What happens with NDMA receptors?

Answer 8

When these are blocked by NDMA antagonists, they mimic pos/neg/cog/affective symptoms

Question 9

What does a blockade of NDMA receptors do?

Answer 9

Creates hypofrontality

Question 10

What is hypfrontality?

Answer 10

Decrease function in prefrontal cortex - association with negative and cognitive deficits.