schizophrenia Flashcards

help

You may prefer our related Brainscape-certified flashcards:
1
Q

what is schizophrenia

A

. serious mental disorder
. characterised by severe disruptions in psychological function
. includes delusions, hallucinations, disorganised speech and behaviour
. all symptoms that disrupt social/occupational functioning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how is schizophrenia classified

A

. using either the DSM-5 or the ICD-10 (international classification of diseases, produced by WHO, contains all disease)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

hoe do the DSM and the ICD differ in classifications of sz

A

. DSM requires at least one positive symptom where ICD does not
. ICD recognises a range of subtypes of sz but DSM had these removed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the DSM-5 criteria for classification of sz

A

A) two symptoms must be present for sig portion of time during 1 m period
- delusions,
- hallucinations
- disorganised speech
- grossly disorganised/ catatonic behaviour
- negative symptoms

B) reduction in 1 or more major areas of functioning

C) continuous signs of disturbance must persist for at least 6 m, at least 1m of active symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the two main types of sz

A

. type 1 sz - positive symptoms
. type 2 sz - negative symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the positive (type 1) symptoms of sz

A

. any behavioural excess
- hallucinations : unusual sensory experiences, 70% of p suffer auditory hallucinations
- delusions: irrational beliefs with no basis in reality, delusions of persecution and delusions of grandeur are most common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the negative (type 2) symptoms of sz

A

. any behavioural defecit
- speech poverty: decrease in fluency and productivity, produce fewer words ue to difficulty spontaneously producing them, often speak with repetetive content or slurring
- avolition: a lack of purposeful/willed or goal orientated behaviour, to be classified, there must be a reduction in self-initiated involvement in activities available to p

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is reliability in diagnosis

A

. the consistency in diagnosis
. in sz, wether there is agreement in diagnosis of sz by different psychiatrists across time and cultures
. known as inter rater reliability
. can also be test-retest reliability in wether diagnostic tests are consistent on different occasions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is co-morbidity

A

. refers to the presence of one or more disorders/diseases simultaneously occurring with sz
. e.g. substance abuse (47%), anxiety (15%), depression (50%)
. suggests sz may not be a seperate disorder
. could lead to professionals giving different diagnosis to same individuals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the issue of culture bias

A

. the extent to which diagnostic system reflects beliefs about what is viewed as normal in predominantly white cultures
. reduces validity of diagnostic system
. both DSM and ICD developed in west, both lack cultural relativism
. affects reliability of diagnostic system, massive variation in diagnosis of sz across cultures, when us and uk clinicians giviven same description of patient diagnosis of sz was 60% us and only 2% uk
. means diagnosis was unreliable across cultures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is validity in diagnosis and classification of sz

A

. teh extent to whixhmethods to measure sz are accurately doing so
. validity assessed using predictive validity, if diagnosis leads to succesful treatment, diagnosis seen as valid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is gender bias in diagnosis and classification of sz

A

. occurs when the accuracy of a diagnosis is dependant on the gender of an individual, diagnostic criteria may be gender biased (it is, its based off male behaviours) or judgements made on stereotypical beliefs about gender
. men are diagnosed more often than women with sz
. women may have better social support
. #feminism male psychiatrists have been proven to diagnose men at a higher rate (56% to 20%) due to biases in diagnostic criteria that base typical behaviours off male behaviours meaning women go undiagnosed and are likely to be diagnosed far later
. this bias did not exist in female psychiatrist
. i hate men
. people of african descent far more likely to be diagnosed as well

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is symptom overlap

A

. occurs when symptoms of sz are also found in other disorders
. makes it difficult for, clinicians to accurately decide om a diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are the weaknesses of sz classification and diagnosis

A

. only has weaknesses icl

. W relaibility - 2 psychiatrists independantly diagnosed 100 p, found inter rater reliability to be poor
- however recent reliability has been increasing, up to 97% in studies using DSM-5
- also criteria provides more understanding for clinicians

. W co morbidity - 50% of ps have substance abuse or depression, difficult to accurately classify as sz or just result of these
- jesse et al found co morbid ps often excluded from research despite making up majority of ps

. w culture bias - in haiti, voices seen as communications from ancestors, africans in uk 9X morel ikely to recieve sz diagnosis, however african countries they arent so not genetic vulnerability
- however this could represent effects of poorer housing, unemployment and social isolation experienced by africans

. W validity - people diagnosed with sz rarely have same symptoms,some never appear to recover from disorder whilst many do

. W - gender bias - males more likely to be commited to looney bins w/ mild symptoms due to risk of social deviance, whereas females more likely to be voluntary, women go incorrectly/underdiagnosed based on gender rather than symptoms

. W symptom overlap - genetic overlap between bipolar and sz, 3 of 7 genomes associated w/ sz also ass with bipolar, both have pos and neg symptoms, may be derived of same condition rather than 2
- people w/ DID also often have more symptoms of sz than ppl diagnosed with sz, means all 3 could be part of the same disorder, reduces validity of diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the dopamine hypothesis (biological)

A

. states positive symptoms caused by overactive transmission of dopamine
. sz have abnormally high levels of D2 receptors on recieving neurons
. allows more dopamine to bind
. leads to problems with attention, perception, and thought
. excess d2 in brocas can cause auditory hallucinations
. low d2 in prefrontal associated with negative symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are the strengths and weaknesses of the dopamine hypothesis (biological)

A

. S support from PET scans, Wong found inc number of D2 receptors in several regions of sz patients, increases validity of hypothesis

. S drug use studies, drugs e.g. coke, meth inc dopamine levels and cause sz like symptoms, parkinsons also due to low dop so treated with l-dopa which inc dop levels, if dose too high experience sz symptoms, support idea that dop is most important factor of sz

. S practical applications, revolutionised treatment as led to anti-psychotic drugs (e.g. chlorpromazine) that reduce the amount of dop in brain to educe positive symptoms, drugs have high success so inc validity of hypothesis

. W drugs affect dopamine levels instantly but it can take weeks for sufferers to reduce in symptoms so reality may be more complex mthan just dopamine

. W atypical drugs like clozapine can be more effective on negative symptoms even though they reduce seratonin levels so hypothesis may be oversimplified and other neurotransmitters may be involved

17
Q

what is enlarged ventricles as an explanation for sz (biological)

A

. enlarged ventricles - larger fluid filled gaps between brain areas
. especially associated with damage to central brain areas and the prefrontal cortex
. discovered using post-mortem, associated with negative symptoms

.neural correlates of neg symptoms - motivation is anticipation of receiving a reward, ventral striatum is involved with anticipation , abnormality in this area may cause avolition
. juckel 2006 measured activity levels in sz and found lower levels of activity than in the control group
. this means activity in the ventral striatum is a neural correlate of negative symptoms

. neural correlates of pos symptoms - Allen 2007 scanned patients with auditory hallu, compared them to control, told to identify prerecorded speech as theirs or others
. hallu group had lower activation of the superior temporal gyrus and the anterior cingulate gyrus, they also made more errors than control
. therefore reduced activity in these areas is a neural correlate of auditory hallu

18
Q

what are the strengths and weaknesses of enlarged ventricles

A

. S supporting evidence - Yoon et al 2013 used fmri scans to find sz had decreased prefrontal cortex activity and less connectivity to other regions when performing a memory task, activity decreased as symptom strength increased - strong scientific credibility and suggest that abnormal functioning is linked to sz cognitive deficits

. W data to support neuaral correlates is mostly correlational, sz symptoms may cause changes in the brain and not all sz have enlarged ventricles, makes it difficult to draw conclusions

. neural correlates no longer accepted as the complete explanation for sz

19
Q

what is the genetic explanation for schizophrenia (biological)

A

. sz passed on through family
. thought that different combinations of genes make people more vulnerable to sz
. sz is thus polygenic
. evidence from family, twin, and adoption studies, used to find concordance rates , mz twins should have higher concordance rates for disorder than dz twins
. Gottesman found children w/ 2 sz parents had concordance of 46%, children w/ 1 had 13% and children with sz sibling had 9%
. NRG3 gene interacts with NRG1 and ERBB4 in cases of sz

20
Q

what re the strenths and weaknesses of genetic explanations of sz (biological)

A

. S twin studies, concordance of 40% OF MZ COMPARED TO 7% DZ, however if only caused by genes mz should have 100%.

. S family studies, verma found 16% of 1st relatives of sz developed szm compared to 7% of control, however inc in sz of those with sz parents could be due to environment

. S adoption studies, allow separation of nature and nurture, Tienari compared adopted children with sz bio mum to control of adopted normal, found higher sz in those with sz bio mum, however found that healthy adoptive family could protect against genetic risks so environment does play part

. S gene mapping, Bunzel found evidence that NRG3, NRG1, ERBB4 interact with eachother to create susceptibility to developing sz, objective evidence,

21
Q

evaluate all biological explanations of sz

A

. all deterministic, state that sz is inevitable in those with correct genes, can be controversial

. couold be seen ad more humane as sufferer not blamed ofr diagnosis, however may make sufferer believe there is nothing they can do

. reductionist as focus only on internal factors and ignore environmental ones, biology alone may not explain all aspects of sz

22
Q

what are typical antipsychotic drugs (bio)

A

. chlorpromazine
. dopamine antagonists - reduce effects of dopamine
. bind to d2 receptors and block them
. reduce positive symptoms of sz

23
Q

what are atypical antipsychotic drugs (bio)

A

. clozapine, risperidone
. newer
. only temporarily block dopamine receptors before dissociating to allow normal transmission
. reduces pos symptoms
. less movement disorders, also effect serotonin so improve neg symptoms

24
Q

what are the strengths and weaknesses of drug therapy (bio)

A

. S supproting research, Thornley 2003 reviewed studies comparing effects of chlorpro on symptoms, found that chlorpro ass with better functioning and reduced symptoms than placebo

. S antipsych are cheap and easy to use and have posotive effects on many sz so they can live lives outside of hospitals, so have practical applications and benefit the economy

. S of atypical, Meltzoff found clozapine more succesful in resistant cases of sz than typical ap, however Healy claims most studies focus on short term effects and pos effects exaggerated and may be untrue

. W side effects, typical ap can lead to movement disorders like Tardive Dyskinesia (involuntary movements of chewing and sucking, twisting and movement of the face) 30% of peopl on ap gain tardive dyskinesia which is irreversible in 75% of cases, however rates are lower in atypical ap - 5% so they may ne more appropriate

. W dropout, side effects reduce compliance, 50% off sz stop medication after 1 year and 75% after 2, culd be due to revolving door syndrome where pat doesnt take medication and regularly relapses, is admitted and treated, then avoid taking when released , questions how appropriate antipsychotics are

25
Q

what is family dysfunction as an explanation for sz (psychological)

A

. claims that risk of sz increases when abnormal patterns of communication is present in the family
. parents of sufferers typically display
- high levels of interpersonal conflict
- difficulty communicatin with eachother
- being excessively critical and controlling of children

includes double bind hypothesis, high expressed emotion, and schizophrenogenic mother

26
Q

what is the double bind hypothesis as an explanation for sz (psych)

A

. Bateson 1956
. children are trapped in sitches where they fear doing wrong but no clear instruction on what right is
. when wrong, parent withdraws love and affection as punishment
. child receives contradictory messages
. results in symptoms like disorganised thinking and paranoia and delusions of persecution
. also leads to negative reaction from child, social withda=rawl and flat effect (lack of emotionsal expression)
. double bind is a risk factor not he sole cause

27
Q

what is high expressed emotion as an explanation for sz (psych)

A

. refers to the level of negative emotion expressed towards a patient by their carers
includes:
- verbal criticism
- hostility towards patient
-emotional over involvement
. high levels of emotion cause patient extreme stress which triggers the onset of sz in a person who is ALREADY GENETICALLY VULNERABLE
. high levels of ee in carers related with poorer outcomes, increased likelihood of relaspe and return to psychotic experiences in sz

28
Q

what is schizophrenogenic mother as an explanation for sz (psych)

A

. fromm-reichmann 1948
. mother is cold, rejecting, controlling
.mother causes family environment characterised by tension nad secrecy
. leads to distrust which can lead to paranoid delusions
. often a dominant mother and apassive father who is uninvolved in a childs life

29
Q

pls write card about diathesis stress model pls pls pls

A