Schizophrenia Flashcards
What are hallucinations?
Unusual sensory experiences that have no basis in reality
Phantom pain
What are delusions?
Irrational beliefs + thought processes
Paranoia and delusions of grandeur
Difference between management and therapy for SZ
Therapy - in and out of clinical setting, reduce symptoms
Management - in clinical setting to make transition into normal life easier
Reliability and validity in SZ AO1
Reliability = consistent
Validity =correct diagnosis of SZ
Co-morbidity = diagnosed with 2 disorders at the same time
Symptom overlap = 1 symptom in 2 disorders
Gender/culture bias
ICD10 = 2 or more negative
DSM5 = 1 or more positive
Reliability and validity in SZ AO3
+ good reliability (180 DSM5) - 0.92 TRT, 0.97 IRR
- cultural bias (Afro-Caribbean)
- Low validity (100) 68 under ICD, 39 under DSM
- symptom overlap: SZ and bipolar (+/- symptoms)
Genetics AO1
High concordance rates in family/twin studies
Gottesman
MZ higher risk than DZ
Polygenic - 108 candidate genes
Ripke (113000, 37000 SZ)
Mutation
Genes affect DA levels
Genetics AO3
+ Tienari (19000 adopted)
+ Objective
+ Practical application - drug treatment
- Social sensitivity: blame/gene editing
Dopamine hypothesis AO1
Neurotransmitter
Abnormal levels cause SZ
Hyperdopaminergia = Broca’s/subcortex (speech poverty/disorganised speech)
Hypodopaminergia = Low dopamine in PFS –> delusions
Dopamine hypothesis AO3
+ Practical application
+ Amphetamine study
- Glutamate
- Cause and effect: dopamine causes SZ or SZ causes dopamine
Neural correlates AO1
Brain structure/function correlates with SZ symptoms
VS - avolition - anticipation of rewards
CG - auditory hallucinations - sound processing
Neural correlates AO3
+ Practical application: brain scans for diagnosis; surgery; pacemaker
+ Objective
+ Reduce stigma
- Correlation vs causation: genes, dopamine, trauma can all cause, or can be effect
Cognitive AO1
Dysfunctional thought processing
LACK OF
- meta-representation: inability to recognise own thoughts/behaviour –> auditory hallucinations (voice in head is their own)
- central control: inability to suppress automatic response while performing a deliberate task –> disorganised speech
Cognitive AO3
+ Stroop 30/30
+ CBT
- SSR stigma
- Not objective - bio better
Family dysfunction AO1
Double bind
SZ mother
Expressed emotion
Family dysfunction AO3
+ Family therapy
- Little evidence/skewed by SZ
- SSR blame family
+ Read: insecure; 69% women and 59% experienced physical/sexual abuse