Schizophrenia Flashcards
Name two aspects of thought disorder
Circumstantiality
Tangentiality
Derailment/knight’s move
Clang association
Flight of ideas
+Poverty of speech, word salad, neologisms, perservation, echolalia
Name one typical antipscyhotic
haloperidol
what is the MOA of antipsychotics?
dopamine antagonist (D2?)
Name two atypical antipscyhotic
clozapine
olanzapine
risperidone
Why did they develop atypical drugs?
due to extrapyramidal effects of typical
Name two extrapyramidal side effects of antipscyhotics
Parkinsonism
neuroleptic malignant syndrome
akinesia
What is a serious side effect of antipscyhotics?
agranulocytosis
What is the half life of fluoxetine?
72 hours (supervisor told me this was an exam question in clinic)
List two non extrapyramidal side effects of antipscyhotics
constipation!!!!! can die from bowel obstruction
weight gain
diabetes/impaired glucose tolerance
raised prolactin
What is a neuro side effect of antipscyhotics?
reduced seizure threshold
What is a cardio side effect of antipsychotics?
prolonged QT
Which antipscyhotic is most commonly associated with prolonged QT?
haloperidol
What are elderly patients on antipscyhotics more at risk of?
stroke
Venous thromboembolism
WHat are the antimuscarinic side effects of antipscyhotics?
dry mouth (think of patient licking their lips!!!)
blurred vision
urinary retention
constipation!
