schizo treatment

Question 1

1
- Question: What are the first-line treatments for schizophrenia according to NICE guidelines?
- Answer:

Answer 1

The first-line treatments for schizophrenia are antipsychotic medications. These include both first-generation antipsychotics (such as Haloperidol) and second-generation antipsychotics (such as Risperidone, Olanzapine, Quetiapine, and Aripiprazole).

Question 2

2
- Question: In what scenario should Aripiprazole be used for treating schizophrenia?
- Answer:

Answer 2

Aripiprazole, a second-generation antipsychotic, can be used as a first-line treatment. It may be chosen based on its side effect profile, particularly when trying to avoid weight gain or metabolic side effects associated with other second-generation antipsychotics.

Question 3

3
- Question: What side effects should be monitored with antipsychotic use in schizophrenia?
- Answer:

Answer 3

Common side effects of antipsychotics include weight gain, extrapyramidal symptoms (like restlessness, rigid muscles, tremors), sedation, and metabolic changes. Regular monitoring of weight, blood pressure, glucose and lipid levels is recommended.

Question 4

4
- Question: When should Clozapine be used in the treatment of schizophrenia according to the NICE guidelines?
- Answer:

Answer 4

Clozapine is a second-generation antipsychotic recommended for use when a person with schizophrenia has not responded to at least two different antipsychotics, one of which should be a non-clozapine second-generation antipsychotic.

Question 5

5
- Question: What side effects should be monitored when using Clozapine for schizophrenia treatment?
- Answer:

Answer 5

Clozapine use requires careful monitoring due to the risk of agranulocytosis (a potentially severe drop in white blood cells). Regular blood tests are mandatory. Other potential side effects include sedation, weight gain, constipation, and potential cardiac effects.

Question 6

6
- Question: What is the role of Long-Acting Injectable (LAI) antipsychotics in schizophrenia treatment according to NICE guidelines?
- Answer:

Answer 6

LAI antipsychotics may be considered for people with schizophrenia who have a preference for this treatment form, or for those who have a history of non-adherence to oral medications leading to relapses.

Question 7

list the first generation Long acting injectables?

Answer 7

Haloperidol decanoate, Fluphenazine decanoate

Question 8

list the second generation Long acting injectables?

Answer 8

Risperidone, Paliperidone palmitate, Olanzapine pamoate, Aripiprazole, Aripiprazole lauroxil