SCC Flashcards
In Mestrinho (JVD 2017), what was the most common intraoral location of OSCC? A) Gingiva B) tonsil C) tongue D) buccal mucosa
Gingiva (61.2%)>tonsil (22%)> tongue> buccal mucosa
In Mestrinho (JVD 2017), which of the following statements was false?
A) Ki67 was significantly associated with LN mets at time of diagnosis, especially in gingival location.
B) LN mets associated with high Ki67 and with tonsillar location, but mean PI did not differ from others.
C) Significant increase for met probability for tumor with high PI and gingival location.
D) Ki67 and PCNA were associated with oral locations.
D) neither were associated with location.
In Mestrinho (JVD 2017), which of the following statements was true?
A) Both markers (Ki67 and PCNA) have a strong nuclear positivity at the center with tumor nests and decreasing toward the periphery
B) Animals with tumor or the tongue tended to be younger and less likely to have met disease at time of diagnosis.
C) PCNA PI was significant with lower PI in grade I
D) Mean expression of Ki67 and PCNA for all tumors was 50% and 62% respectively
C)
Strong positivity at the periphery decreasing toward the center
Tumors of the tongue older and met disease at time of diagnosis
Ki67 62%, PCNA 50%
Grade II most frequently diagnosed
Grade I in gingiva and buccal mucosa
Grade III in gingiva and tonsil
According to Rejec evaluation of accelerated chemoradiotherapy for oropharyngeal SCC in 5 cats and 3 dogs. Which of the following is false?
A) Complete response was seen in 4/5 cats with partial response in 1/5 cats
B) 2/3 dogs achieved complete response by 6 to 10 weeks after completion of therapy.
C) The most significant toxicity occurred in the mucosa
D) the ineffectiveness of conventional radiation is explained by hypoxic cells.
B) complete response and long term survival achieved in all canine patients.
According to Bilgic, what was associated with increased risk of SCC?
Tobacco smoke (2x) Flea collars (5.3x) Canned Food (3.6x) Canned Tuna (4.7x)
According to Bilgic, what is the suspected cause of increased risk associated with tobacco smoke in feline SCC?
mutation in tumor suppressor gene p53
In Solter-Rivera prevalence of regional and distant mets in cats with advanced oral SCC, what percentage of cats had pulmonary mets? A) 10% B) 23% C) 31% D) 5%
10%
In Solter-Rivera, prevalence of regional and distant mets in cats with advanced oral SCC, what was the most common tumor location?
A) Maxilla
B) sublingual
C) Mandible
D) caudal pharyngeal/tonsil
A) Maxilla (39%)>sublingual (33%)> MN (25%) > caudal pharyngeal/tonsil
In Solter-Rivera, prevalence of regional and distant mets in cats with advanced oral SCC, what percentage of cats had LN mets?
A) 10%
B) 23%
C) 31%
D) 5%
C) 31%
In Solter-Rivera, prevalence of regional and distant mets in cats with advanced oral SCC, which of the following were associated with survival time?
A) Presence of mets in the lungs
B) tumor volume
C) presence of mets in the LN
D) Maxillary location
Maxillary location associated with longer survival, the others not associated including surprisingly mets
Neither tumor location or volume was associated with development of mets.
In Ibarra, malignant transformation of CPV induced oral papilloma in the dog, what two types of CPV are associated with malignant transformation? A) 1 B) 13 C) 17 D) 19
all four associated with oral lesions
1 and 17 are associated with malignant transformation.
In Ibarra, malignant transformation is hypothesized to be associated with inadequate cellular immunity and a latent CPV-1 infection that was reactivated by what? A) inflammation B) trauma C) periodontal disease D) virulence factors of oral bacteria
B) trauma
According to Fulton, risk factors associated with survival in tonsillar SCC in dogs, what was the most common location? A) Caudal MN B) Rostral MX C) Caudal MX D) Rostral MN
D) Rostral mandible 37%>caudal MX>Rostral MX>Caudal MN.
According to Fulton, risk factors associated with survival in tonsillar SCC in dogs, which of the following were statistically significant in association with ST? A) location B) clinical stage C) histo subtype D) age
all were not statistically associated with ST
Age was not statistically significant 1 year survival rate decreased as age increased.
1 year survival for all operated was 93.5%
MST for untreated dogs 54d, with surgery MST>10yo was 365d, <10yo MST not reached.
According to Fidel, treatment of SCC with accelerated radiation therapy and concomitant carboplatin, which of the following were considered predictors of survival? A) Site B) complete response within 30d C) Stage D) Size
A and B
Stage, size and mets not considered predictors.
Tonsil and cheek were the site with the longest ST at 724d and median was not reached.
