Melanoma Flashcards

1
Q

According to Touhy (JAVMA 2014), which of the follwoing is false?

A) Curative intent surgery was best (PFI>567d, ST=874d)
B) Every 1cm of tumor size increased hazard of death by 32% of local recurrence and metastasis (29%).
C) Adjuvant therapy had a 30% decreased hazard of death.
D) Type, location and incomplete margin had no assoication with hazard of death in this study.

A

C) Adjuvant therapy had a 30% decreased hazard of death.

Adjuvant therapy increased hazard of death by 30%, Tumor size only variable associated with increased hazard of deat.

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2
Q
According to Carrol (JAVMA 2020), what singular variable of histologic grade showed a significant relationship with tumor size?
A) cellular atypia
B) presence of distant mets
C) lymphatic invasion
D) amelanotic v. melanotic lesions
A

C) lymphatic invasion

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3
Q
According to Carroll (JAVMA 2020), lymphatic invasion can effectively be ruled out for tumors < \_\_\_\_ mm in diameter and ruled in for tumors > \_\_\_ mm in size?
A) 12mm, 24mm
B) 6.5mm, 24mm
C) 6.5mm, 32mm
D) 1mm, 32mm
A

6.5mm (100% sensitivity) and 24mm (100%) specificity

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4
Q

According to Texeira, which of the following is true?
A) Amelanotic variants showed slower growth
B) cell proliferation was significantly lower in amelanotic variants
C) Expression of connexin 26 and 43 significantly reduced in amelanotic melanomas
D) All results indicate amelanotic melanomas are a less aggressive variant.

A

Amelanotics faster growth, cell proliferation was higher and are more aggressive.

C) Connexins were also more cytoplasmic in location indicating disruption of gap junctions and decreased communication.

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5
Q

According to Boston, Efficacy of systemic adjuvant therapies administered to dogs after excision of MM, which of is true?
A) Increased tumor size and age were not prognositc
B) Intralesional excision had no prognostic effect
C) There was on difference in survival times with and without adjuvant chemotherapy
D) Complete excision of all of the macroscopic tumor border did not improve survival time.

A

C is true.

Increased tumor size, increased age, and an intralesional incision were negative prognostic indicators.

Complete excision of all macroscopic tumor improved survival time.

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6
Q
According to Boston, Efficacy of systemic adjuvant therapies administered to dogs after excision of MM, what was the MST with surgical treatment?
A) 346d
B) 162d
C) 524d
D) 215d
A

A) 346d, 29% long term survival.

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7
Q

What is true regarding the xenogenic DNA vax for OMM?

A

Results showed that dogs that got the hyTyr vaccine had significantly improved survival times but MST could not be determined before the end of the study becasue <50% died of OMM before end of study. Used historical records.

There was no significant difference between vaccinates ST for complete, incomplete or equivocal margins.

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8
Q

According to Murikami, which of the following is false?
A) 51% of dogs (+) for kit protein
B) no significant difference between kit expression and survival
C) Mutations were present on axon 11 which is similarly noted in humans.
D) No association between kit expression and WHO staging

A

C mutation was not in dogs, though it is seen in humans.

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